4.6 Review

Pulmonary surfactant: a unique biomaterial with life-saving therapeutic applications

Related references

Note: Only part of the references are listed.
Article Obstetrics & Gynecology

Nebulization of High-Dose Poractant Alfa in Newborn Piglets on Nasal Continuous Positive Airway Pressure Yields Therapeutic Lung Doses of Phospholipids

Anders Nord et al.

Summary: This study demonstrates that nebulizing a high dose of poractant alfa using a vibrating-membrane nebulizer in newborn piglets on nCPAP can achieve therapeutic lung doses of phospholipids similar to instillation of synthetic surfactant. The lung dose of phospholipids during nebulization was well tolerated and not significantly different from the instillation group.

AMERICAN JOURNAL OF PERINATOLOGY (2022)

Review Pediatrics

Supraglottic airway devices for administration of surfactant to newborn infants with respiratory distress syndrome: a narrative review

Calum T. Roberts et al.

Summary: Surfactant is an effective treatment for respiratory distress syndrome, with supraglottic airway devices potentially providing an attractive option for delivery. However, further research is needed to verify their safety and effectiveness before routine clinical use.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2021)

Article Pediatrics

Comparative efficacy of methods for surfactant administration: a network meta-analysis

Ioannis Bellos et al.

Summary: The study compared different methods of surfactant administration and found that using thin catheters was associated with lower risks of mortality, mechanical ventilation, and bronchopulmonary dysplasia in preterm infants compared to other methods.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2021)

Article Chemistry, Multidisciplinary

Pulmonary surfactant and drug delivery: Vehiculization, release and targeting of surfactant/tacrolimus formulations

Alberto Hidalgo et al.

Summary: This study demonstrated the potential of using pulmonary surfactant (PS) for drug delivery over the respiratory air-liquid interface in both in vitro and in vivo settings. The combination of PS with the hydrophobic anti-inflammatory drug Tacrolimus showed enhanced efficiency in drug delivery, particularly in attenuating the pro-inflammatory effects of LPS-induced acute lung injury. These results suggest a synergistic anti-inflammatory effect of PS/drug formulations, opening up novel effective delivery strategies for inhaled drugs.

JOURNAL OF CONTROLLED RELEASE (2021)

Article Pediatrics

Surfactant lung delivery with LISA and InSurE in adult rabbits with respiratory distress

Francesca Ricci et al.

Summary: In a study on surfactant-depleted adult rabbits, the LISA technique demonstrated efficacy and similar surfactant lung delivery to InSurE in terms of gas exchange, ventilation parameters, and lung mechanics. The findings suggest that LISA could be as effective as InSurE and provide clarification on a fair comparison between the two techniques, particularly in terms of surfactant delivery.

PEDIATRIC RESEARCH (2021)

Review Respiratory System

The COVID-19 pandemic: a target for surfactant therapy?

Ruud A. W. Veldhuizen et al.

Summary: The impact of COVID-19 has led to a search for effective treatment approaches, with exogenous surfactant being considered as a potential therapy for COVID-19 patients. The success of this therapy could be influenced by various factors such as mechanical ventilation strategy, timing of treatment, doses delivered, method of delivery, and preparations utilized. Development of enhanced preparations may improve the effectiveness of this treatment approach, and ongoing trials may provide valuable data and insights for further scientific understanding and improved treatment strategies.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2021)

Review Chemistry, Physical

Exogenous pulmonary surfactant: A review focused on adjunctive therapy for severe acute respiratory syndrome coronavirus 2 including SP-A and SP-D as added clinical marker

Amit Ghati et al.

Summary: Type II pneumocytes secrete pulmonary surfactants and are preferentially targeted by certain respiratory diseases, leading to lung damage. Exogenous pulmonary surfactant therapy has been successful in treating respiratory diseases and has potential for preventing respiratory failure associated with severe acute respiratory syndrome coronavirus 2. Early detection of surfactant collectins in the circulatory system may serve as a significant clinical marker for disease prognosis in the future.

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE (2021)

Article Anatomy & Morphology

Evaluation of recombinant human SP-D in the rat premature lung model

Raquel Arroyo et al.

Summary: The study developed and validated a preclinical model of early alveolarization and structurally premature lungs in 10-day-old rats, demonstrating that intratracheal administration of rhSP-D at a dose of 8 mg/kg did not induce inflammation or toxicity in premature lungs even with daily administration for 14 days. The pharmacokinetic distribution of rhSP-D in premature lungs had a half-life of approximately 9 hours and minimal incorporation into blood.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2021)

Review Respiratory System

Aerosol drug delivery to spontaneously-breathing preterm neonates: lessons learned

Federico Bianco et al.

Summary: The delivery of medications to preterm neonates receiving non-invasive ventilation (NIV) is a challenging scenario for aerosol medicine due to anatomical and physiological characteristics of the lungs in such infants. Factors such as low lung volumes, compliance, and irregular respiratory rates affect lung deposition. Extrinsic factors like aerosol generator choice, drug formulation, particle size distribution, NIV type, and patient interface also impact lung deposition and offer an opportunity to optimize therapy efficacy. Existing experimental and clinical data on neonatal aerosol delivery are examined, with a focus on non-invasive delivery of surfactant aerosols, providing insights and a framework for the development of inhaled drugs in this patient population.

RESPIRATORY RESEARCH (2021)

Article Pediatrics

Budesonide with surfactant decreases systemic responses in mechanically ventilated preterm lambs exposed to fetal intra-amniotic lipopolysaccharide

Noah H. Hillman et al.

Summary: The addition of budesonide to surfactant in preterm lambs exposed to intra-amniotic LPS improved physiology and markers of lung and systemic inflammation, showing potential for decreasing lung inflammation in preterm infants with chorioamnionitis.

PEDIATRIC RESEARCH (2021)

Article Critical Care Medicine

Effect of Whole Body Hypothermia on Surfactant Function When Amniotic Fluid Is Meconium Stained

Chiara Autilio et al.

THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT (2020)

Article Respiratory System

Deposition of Aerosolized Lucinactant in Nonhuman Primates

Timothy J. Gregory et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2020)

Article Chemistry, Physical

SP-B and SP-C analogues within CHF5633 synthetic surfactant probed by fluorescence labeling

Luca Ronda et al.

JOURNAL OF MOLECULAR LIQUIDS (2020)

Article Pediatrics

Surfactant and budesonide for respiratory distress syndrome: an observational study

T. Brett Kothe et al.

PEDIATRIC RESEARCH (2020)

Article Physiology

Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep

Noah H. Hillman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

Air Space Distension Precedes Spontaneous Fibrotic Remodeling and Impaired Cholesterol Metabolism in the Absence of Surfactant Protein C

Jannik Ruwisch et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Pulmonary Surfactant Lipid Reorganization Induced by the Adsorption of the Oligomeric Surfactant Protein B Complex

Juho Liekkinen et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

Review Pediatrics

Surfactant replacement therapy: from biological basis to current clinical practice

Roland Hentschel et al.

PEDIATRIC RESEARCH (2020)

Article Biochemistry & Molecular Biology

Surfactant Injury in the Early Phase of Severe Meconium Aspiration Syndrome

Chiara Autilio et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Lipid-Protein and Protein-Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis

Olga Canadas et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Cell & Tissue Engineering

Organoids as a Powerful Model for Respiratory Diseases

Yu Li et al.

STEM CELLS INTERNATIONAL (2020)

Editorial Material Immunology

Editorial: Odyssey of Surfactant Proteins SP-A and SP-D: Innate Immune Surveillance Molecules

Uday Kishore et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Pediatrics

Endotracheal Surfactant Combined With Budesonide for Neonatal ARDS

Burak Deliloglu et al.

FRONTIERS IN PEDIATRICS (2020)

Letter Critical Care Medicine

Lung Mechanics in COVID-19 Resemble Respiratory Distress Syndrome, Not Acute Respiratory Distress Syndrome: Could Surfactant Be a Treatment?

Anastassios C. Koumbourlis et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Article Biochemistry & Molecular Biology

Pulmonary surfactant protein SP-B nanorings induce the multilamellar organization of surfactant complexes

Marta Martinez-Calle et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

Article Biophysics

Atomic Force Microscopy Imaging of Adsorbed Pulmonary Surfactant Films

Lu Xu et al.

BIOPHYSICAL JOURNAL (2020)

Review Pharmacology & Pharmacy

Extrapulmonary Surfactant Therapy: Review of Available Data and Research/Development Issues

Silvia Foligno et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2020)

Article Medicine, General & Internal

Lung Surfactant for Pulmonary Barrier Restoration in Patients With COVID-19 Pneumonia

Ursula Mirastschijski et al.

FRONTIERS IN MEDICINE (2020)

Article Chemistry, Physical

Interactions of particulate matter and pulmonary surfactant: Implications for human health

Feifei Wang et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2020)

Article Physiology

Intratracheal budesonide/surfactant attenuates hyperoxia-induced lung injury in preterm rabbits

Andre G. Gie et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

Article Multidisciplinary Sciences

Optimizing Exogenous Surfactant as a Pulmonary Delivery Vehicle for Chicken Cathelicidin-2

Brandon Baer et al.

Scientific Reports (2020)

Editorial Material Pediatrics

Aerosolized Calfactant in Infants With RDS: Surfactant Replacement 2.0?

Kirsten Glaser et al.

PEDIATRICS (2020)

Article Medicine, Research & Experimental

Pulmonary surfactant itself must be a strong defender against SARS-CoV-2

Hideyuki Takano

MEDICAL HYPOTHESES (2020)

Article Pediatrics

Nebulised surfactant to reduce severity of respiratory distress: a blinded, parallel, randomised controlled trial

Stefan Minocchieri et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2019)

Article Pharmacology & Pharmacy

New insights into exogenous surfactant as a carrier of pulmonary therapeutics

Brandon Baer et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Review Pediatrics

Genetic causes of surfactant protein abnormalities

Lawrence M. Nogee

CURRENT OPINION IN PEDIATRICS (2019)

Editorial Material Respiratory System

Advances in synthetic lung surfactant protein technology

Frans J. Walther et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2019)

Article Medicine, General & Internal

Acute respiratory distress syndrome

Michael A. Matthay et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

Review Pharmacology & Pharmacy

Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes

Maliheh Ghadiri et al.

PHARMACEUTICS (2019)

Article Biochemistry & Molecular Biology

Helical side chain chemistry of a peptoid-based SP-C analogue: Balancing structural rigidity and biomimicry

Nathan J. Brown et al.

BIOPOLYMERS (2019)

Review Pediatrics

Less invasive surfactant administration (LISA): chances and limitations

Egbert Herting et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2019)

Review Biochemistry & Molecular Biology

Brain oxidative damage in murine models of neonatal hypoxia/ischemia and reoxygenation

Isabel Torres-Cuevas et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Pharmacology & Pharmacy

The Lord of the Lungs: The essential role of pulmonary surfactant upon inhalation of nanoparticles

Cristina Garcia-Mouton et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

Review Pediatrics

Understanding the principle biophysics concepts of pulmonary surfactant in health and disease

Chiara Autilio et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2019)

Review Oncology

Lessons learned in acute respiratory distress syndrome from the animal laboratory

Nadir Yehya

ANNALS OF TRANSLATIONAL MEDICINE (2019)

Article Respiratory System

Natural Derived Surfactant Preparation As a Carrier of Polymyxin E for Treatment of Pseudomonas aeruginosa Pneumonia in a Near-Term Rabbit Model

Oihana Basabe-Burgos et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2019)

Review Obstetrics & Gynecology

Supraglottic airway devices for surfactant treatment: systematic review and meta-analysis

Maria Grazia Calevo et al.

JOURNAL OF PERINATOLOGY (2019)

Editorial Material Critical Care Medicine

Personalising care of acute respiratory distress syndrome according to patients' age

Daniele De Luca

LANCET RESPIRATORY MEDICINE (2019)

Article Critical Care Medicine

Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study

Robinder G. Khemani et al.

LANCET RESPIRATORY MEDICINE (2019)

Article Physiology

Surfactant plus budesonide decreases lung and systemic inflammation in mechanically ventilated preterm sheep

T. Brett Kothe et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

Article Physiology

Effects of budesonide and surfactant in preterm fetal sheep

T. Brett Kothe et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Dysfunction of pulmonary surfactant mediated by phospholipid oxidation is cholesterol-dependent

Mustafa Al-Saiedy et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)

Article Biophysics

Penetration of antimicrobial peptides in a lung surfactant model

L. M. P. Souza et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

Article Biochemistry & Molecular Biology

Pulmonary surfactant protein SP-B promotes exocytosis of lamellar bodies in alveolar type II cells

Marta Martinez-Calle et al.

FASEB JOURNAL (2018)

Article Biochemistry & Molecular Biology

Supramolecular Assembly of Human Pulmonary Surfactant Protein SP-D

R. Arroyo et al.

JOURNAL OF MOLECULAR BIOLOGY (2018)

Article Medicine, General & Internal

Surfactant Dysfunction in ARDS and Bronchiolitis is Repaired with Cyclodextrins

Mustafa Al-Saiedy et al.

MILITARY MEDICINE (2018)

Article Biochemistry & Molecular Biology

Metabolism of a synthetic compared with a natural therapeutic pulmonary surfactant in adult mice

Jens Madsen et al.

JOURNAL OF LIPID RESEARCH (2018)

Article Multidisciplinary Sciences

Inhibition and counterinhibition of Surfacen, a clinical lung surfactant of natural origin

Yuliannis Lugones et al.

PLOS ONE (2018)

Article Multidisciplinary Sciences

Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis

Cormac McCarthy et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Multidisciplinary

Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins

Roberta Guagliardo et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Medicine, General & Internal

Surfactant Protein D in Respiratory and Non-Respiratory Diseases

Grith L. Sorensen

FRONTIERS IN MEDICINE (2018)

Review Oncology

New insights into the mechanisms of pulmonary edema in acute lung injury

Raquel Herrero et al.

ANNALS OF TRANSLATIONAL MEDICINE (2018)

Review Cell Biology

Lung surfactant metabolism: early in life, early in disease and target in cell therapy

Elena Lopez-Rodriguez et al.

CELL AND TISSUE RESEARCH (2017)

Review Cell Biology

The biology of the ABCA3 lipid transporter in lung health and disease

Michael F. Beers et al.

CELL AND TISSUE RESEARCH (2017)

Article Respiratory System

Abstracts: International Society for Aerosols in Medicine e.V. 21st ISAM Congress Santa Fe, NM June 3–7, 2017

Journal of Aerosol Medicine and Pulmonary Drug Delivery (2017)

Review Anesthesiology

Comparison of laryngeal mask airway vs tracheal intubation: a systematic review on airway complications

Babette F. van Esch et al.

JOURNAL OF CLINICAL ANESTHESIA (2017)

Article Cardiac & Cardiovascular Systems

Lung lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury

Daisuke Nakajima et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2017)

Article Chemistry, Multidisciplinary

Efficient Interfacially Driven Vehiculization of Corticosteroids by Pulmonary Surfactant

Alberto Hidalgo et al.

LANGMUIR (2017)

Article Multidisciplinary Sciences

Effect of cholesterol on the molecular structure and transitions in a clinical-grade lung surfactant extract

Jenny Marie Andersson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Efficient protein production inspired by how spiders make silk

Nina Kronqvist et al.

NATURE COMMUNICATIONS (2017)

Article Critical Care Medicine

The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity

Daniele De Luca et al.

LANCET RESPIRATORY MEDICINE (2017)

Review Pharmacology & Pharmacy

Liposomal Formulations in Clinical Use: An Updated Review

Upendra Bulbake et al.

PHARMACEUTICS (2017)

Article Anatomy & Morphology

Pulmonary surfactant metabolism in the alveolar airspace: Biogenesis, extracellular conversions, recycling

Barbara Olmeda et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2017)

Article Biophysics

Interaction of levofloxacin with lung surfactant at the air-water interface

Stephanie Ortiz-Collazos et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

Article Biochemistry & Molecular Biology

Pulmonary surfactant and nanocarriers: Toxicity versus combined nanomedical applications

Alberto Hidalgo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2017)

Article Biochemistry & Molecular Biology

Restoring pulmonary surfactant membranes and films at the respiratory surface

Mercedes Echaide et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2017)

Article Anatomy & Morphology

Aberrant lung remodeling in a mouse model of surfactant dysregulation induced by modulation of the Abca3 gene

Michael F. Beers et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2017)

Article Critical Care Medicine

Intratracheal Administration of Budesonide/Surfactant to Prevent Bronchopulmonary Dysplasia

Tsu F. Yeh et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

Article Anatomy & Morphology

Recombinant expression of surfactant protein H (SFTA3) in Escherichia coli

H. Schroeder et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2016)

Review Anatomy & Morphology

Lung surfactant: Function and composition in the context of development and respiratory physiology

Wolfgang Bernhard

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2016)

Article Biophysics

Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films

Elena Lopez-Rodriguez et al.

BIOPHYSICAL JOURNAL (2016)

Article Biochemistry & Molecular Biology

Surfactant protein A: A key player in lung homeostasis

Nadia Nathan et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Review Medicine, General & Internal

Association of Noninvasive Ventilation Strategies With Mortality and Bronchopulmonary Dysplasia Among Preterm Infants A Systematic Review and Meta-analysis

Tetsuya Isayama et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Pediatrics

Effect of Minimally Invasive Surfactant Therapy on Lung Volume and Ventilation in Preterm Infants

Pauline S. van der Burg et al.

JOURNAL OF PEDIATRICS (2016)

Article Pharmacology & Pharmacy

Pharmacokinetics of Budesonide Administered with Surfactant in Premature Lambs: Implications for Neonatal Clinical Trials

Jessica K. Roberts et al.

CURRENT CLINICAL PHARMACOLOGY (2016)

Article Biochemistry & Molecular Biology

Palmitoylation as a key factor to modulate SP-C-lipid interactions in lung surfactant membrane multilayers

Nuria Roldan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2015)

Review Biochemistry & Molecular Biology

Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

Elisa Parra et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2015)

Article Critical Care Medicine

The Adult Calfactant in Acute Respiratory Distress Syndrome Trial

Douglas F. Willson et al.

CHEST (2015)

Article Pharmacology & Pharmacy

Barrier or carrier? Pulmonary surfactant and drug delivery

Alberto Hidalgo et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Review Nanoscience & Nanotechnology

Liposomes as nanomedical devices

Giuseppina Bozzuto et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2015)

Article Chemistry, Multidisciplinary

Bio-inspired pulmonary surfactant-modified nanogels: A promising siRNA delivery system

Lynn De Backer et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Meeting Abstract Cardiac & Cardiovascular Systems

Lung Lavage and Surfactant Administration for the Ex Vivo Pre-Transplant Treatment of Donor Lungs Injured Due to Gastric Add Aspiration

D. Nakajima et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2015)

Article Pediatrics

Surfactant protein B and A concentrations are increased in neonatal pneumonia

Sara D'Aronco et al.

PEDIATRIC RESEARCH (2015)

Article Pediatrics

Effect of Surfactant and Budesonide on the Pulmonary Distribution of Fluorescent Dye in Mice

Liang-Ti Huang et al.

PEDIATRICS AND NEONATOLOGY (2015)

Article Multidisciplinary Sciences

Surfactant Lipidomics in Healthy Children and Childhood Interstitial Lung Disease

Matthias Griese et al.

PLOS ONE (2015)

Review Medicine, General & Internal

Acute otitis media

Helen Atkinson et al.

POSTGRADUATE MEDICINE (2015)

Article Multidisciplinary Sciences

Three-dimensional model of surfactant replacement therapy

Marcel Filoche et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Critical Care Medicine

Evaluation of endothelial damage in sepsis-related ARDS using circulating endothelial cells

Mouhamed Djahoum Moussa et al.

INTENSIVE CARE MEDICINE (2015)

Review Medicine, General & Internal

Comparison of animal-derived surfactants for the prevention and treatment of respiratory distress syndrome in preterm infants

Neetu Singh et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2015)

Review Medicine, General & Internal

Surfactant therapy for bronchiolitis in critically ill infants

Kana R. Jat et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2015)

Review Medicine, General & Internal

Animal models, learning lessons to prevent and treat neonatal chronic lung disease

Alan H. Jobe

FRONTIERS IN MEDICINE (2015)

Review Medicine, General & Internal

Animal derived surfactant extract versus protein free synthetic surfactant for the prevention and treatment of respiratory distress syndrome

Stephanie Ardell et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2015)

Article Critical Care Medicine

Ventilator-induced Lung Injury

Martin C. J. Kneyber et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

Article Biochemistry & Molecular Biology

Short-Term Cigarette Smoke Exposure Leads to Metabolic Alterations in Lung Alveolar Cells

Amit R. Agarwal et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Structure-function relationships in pulmonary surfactant membranes: From biophysics to therapy

Elena Lopez-Rodriguez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)

Article Chemistry, Physical

Impairing effect of fibrinogen on the mono-/bi-layer form of bovine lung surfactant

Ravi Devraj et al.

COLLOID AND POLYMER SCIENCE (2014)

Article Respiratory System

SFTA3, a novel protein of the lung: three-dimensional structure, characterisation and immune activation

Martin Schicht et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

Letter Respiratory System

Effect of whole body hypothermia on inflammation and surfactant function in asphyxiated neonates

Daniele De Luca et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

Article Genetics & Heredity

Novel ABCA3 mutations as a cause of respiratory distress in a term newborn

Jean-Pierre Goncalves et al.

Review Pediatrics

The Molecular Era of Surfactant Biology

Jeffrey A. Whitsett

NEONATOLOGY (2014)

Article Pediatrics

Surfactant-Associated Proteins: Structure, Function and Clinical Implications

Anastasia K. Ketko et al.

CURRENT PEDIATRIC REVIEWS (2014)

Review Medicine, General & Internal

Surfactant for meconium aspiration syndrome in term and late preterm infants

Amr I. El Shahed et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2014)

Review Pharmacology & Pharmacy

Liposomal drug delivery systems: From concept to clinical applications

Theresa M. Allen et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Article Cardiac & Cardiovascular Systems

Surfactant Improves Graft Function After Gastric Acid-Induced Lung Damage in Lung Transplantation

Ilhan Inci et al.

ANNALS OF THORACIC SURGERY (2013)

Article Biochemistry & Molecular Biology

Lysoglycerophospholipids in chronic inflammatory disorders: The PLA(2)/LPC and ATX/LPA axes

Ioanna Sevastou et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)

Review Biochemistry & Molecular Biology

Peptide Design for Antimicrobial and Immunomodulatory Applications

Evan F. Haney et al.

BIOPOLYMERS (2013)

Editorial Material Immunology

Editorial overview: Innate immunity

Jules Hoffmann et al.

CURRENT OPINION IN IMMUNOLOGY (2013)

Review Biophysics

Structure-function correlations of pulmonary surfactant protein SP-B and the saposin-like family of proteins

Barbara Olmeda et al.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2013)

Meeting Abstract Cardiac & Cardiovascular Systems

Lung Injuries Induced by Gastric Acid Aspiration Are Attenuated by Exogenous Surfactant during Ex Vivo Reconditioning in Pigs

T. Khalife et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2013)

Article Medicine, Research & Experimental

Pathological Study of Otitis Media With Effusion After Treatment With Intranasal Pulmonary Surfactant

Zheng Hua Zhu et al.

LARYNGOSCOPE (2013)

Article Physiology

Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids

R. Duncan Hite et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2012)

Article Medicine, General & Internal

Secretory Phospholipase A2-Mediated Depletion of Phosphatidylglycerol in Early Acute Respiratory Distress Syndrome

Michael C. Seeds et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2012)

Article Biochemistry & Molecular Biology

A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant

Eleonora Keating et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)

Review Biochemistry & Molecular Biology

Role of lipid ordered/disordered phase coexistence in pulmonary surfactant function

Cristina Casals et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)

Article Biochemistry & Molecular Biology

Interfacial behavior and structural properties of a clinical lung surfactant from porcine source

Odalys Blanco et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)

Review Nanoscience & Nanotechnology

Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy

Hsin-I Chang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2012)

Article Medicine, General & Internal

Acute Respiratory Distress Syndrome The Berlin Definition

V. Marco Ranieri et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

Review Biotechnology & Applied Microbiology

Diverse Functions of Pulmonary Collectins in Host Defense of the Lung

Shigeru Ariki et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012)

Article Respiratory System

Anionic pulmonary surfactant lipid regulation of innate immunity

Mari Numata et al.

EXPERT REVIEW OF RESPIRATORY MEDICINE (2012)

Review Medicine, General & Internal

Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome

Felicia L. Bahadue et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2012)

Article Critical Care Medicine

Recombinant Surfactant Protein C-based Surfactant for Patients with Severe Direct Lung Injury

Roger G. Spragg et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Article Biochemistry & Molecular Biology

Role of Endoplasmic Reticulum Stress in Epithelial-Mesenchymal Transition of Alveolar Epithelial Cells

Qian Zhong et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Comparative study of clinical pulmonary surfactants using atomic force microscopy

Hong Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)

Article Biophysics

Meconium Impairs Pulmonary Surfactant by a Combined Action of Cholesterol and Bile Acids

Elena Lopez-Rodriguez et al.

BIOPHYSICAL JOURNAL (2011)

Article Biophysics

Biomimetic N-Terminal Alkylation of Peptoid Analogues of Surfactant Protein C

Nathan J. Brown et al.

BIOPHYSICAL JOURNAL (2011)

Article Critical Care Medicine

Surfactant Therapy for Acute Lung Injury and Acute Respiratory Distress Syndrome

Krishnan Raghavendran et al.

CRITICAL CARE CLINICS (2011)

Review Pediatrics

Aerosol delivery to ventilated newborn infants: historical challenges and new directions

Jan Mazela et al.

EUROPEAN JOURNAL OF PEDIATRICS (2011)

Article Respiratory System

Beneficial effects of synthetic KL4 surfactant in experimental lung transplantation

A. Saenz et al.

EUROPEAN RESPIRATORY JOURNAL (2011)

Letter Respiratory System

Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations

T. Suzuki et al.

EUROPEAN RESPIRATORY JOURNAL (2011)

Review Immunology

Host defense peptides and their antimicrobial-immunomodulatory duality

Lars Steinstraesser et al.

IMMUNOBIOLOGY (2011)

Article Critical Care Medicine

Role of distinct phospholipases A2 and their modulators in meconium aspiration syndrome in human neonates

Daniele De Luca et al.

INTENSIVE CARE MEDICINE (2011)

Review Respiratory System

Development of an Inhaled Dry-Powder Formulation of Tobramycin Using PulmoSphere™ Technology

David E. Geller et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2011)

Article Genetics & Heredity

Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB

Takeshi Tanaka et al.

JOURNAL OF MEDICAL GENETICS (2011)

Article Chemistry, Multidisciplinary

On the Low Surface Tension of Lung Surfactant

Hong Zhang et al.

LANGMUIR (2011)

Article Nanoscience & Nanotechnology

Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A

Christian A. Ruge et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

Article Critical Care Medicine

Secretory phospholipase A(2) pathway during pediatric acute respiratory distress syndrome: A preliminary study

Daniele De Luca et al.

PEDIATRIC CRITICAL CARE MEDICINE (2011)

Article Pediatrics

Serum SP-D Levels as a Biomarker of Lung Injury in Respiratory Syncytial Virus Bronchiolitis

Yukihiko Kawasaki et al.

PEDIATRIC PULMONOLOGY (2011)

Article Physiology

Pathway to lamellar bodies for surfactant protein A

Aron B. Fisher et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2010)

Article Physiology

Role of cholesterol in the biophysical dysfunction of surfactant in ventilator-induced lung injury

Dan Vockeroth et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2010)

Article Critical Care Medicine

Surfactant Protein-D Inhibits Lung Inflammation Caused by Ventilation in Premature Newborn Lambs

Atsuyasu Sato et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

Review Medicine, Research & Experimental

Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary Disease

Jeffrey A. Whitsett et al.

ANNUAL REVIEW OF MEDICINE (2010)

Article Biochemistry & Molecular Biology

Mimicking SP-C palmitoylation on a peptoid-based SP-B analogue markedly improves surface activity

Michelle T. Dohm et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2010)

Review Biochemistry & Molecular Biology

Overcoming rapid inactivation of lung surfactant: Analogies between competitive adsorption and colloid stability

Joseph A. Zasadzinski et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2010)

Article Biochemistry & Molecular Biology

Pulmonary surfactant layers accelerate O2 diffusion through the air-water interface

Barbara Olmeda et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2010)

Article Otorhinolaryngology

Effect of Nebulized Bovine Surfactant for Experimental Otitis Media with Effusion

Chul Ho Jang et al.

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY (2010)

Article Biochemistry & Molecular Biology

Fluidizing effects of C-reactive protein on lung surfactant membranes: protective role of surfactant protein A

Alejandra Saenz et al.

FASEB JOURNAL (2010)

Article Otorhinolaryngology

Efficacy of transnasal nebulized surfactant on experimental otitis media with effusion in guinea pig

Chul Ho Jang et al.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2010)

Article Respiratory System

An Open Label, Pilot Study of Aerosurf® Combined with nCPAP to Prevent RDS in Preterm Neonates

Neil N. Finer et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2010)

Article Biochemistry & Molecular Biology

Lamellar Bodies Form Solid Three-dimensional Films at the Respiratory Air-Liquid Interface

Andrea Ravasio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Chemistry, Physical

Physicochemical studies on the interaction of serum albumin with pulmonary surfactant extract in films and bulk bilayer phase

Kaushik Nag et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2010)

Article Chemistry, Multidisciplinary

Interfacial Reactions of Ozone with Surfactant Protein B in a Model Lung Surfactant System

Hugh I. Kim et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Chemistry, Multidisciplinary

Nanomechanics of Lipid Bilayers: Heads or Tails?

Sergi Garcia-Manyes et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Review Physiology

Pulmonary Surfactant Pathophysiology: Current Models and Open Questions

Jesus Perez-Gil et al.

PHYSIOLOGY (2010)

Article Pediatrics

Normal Development of the Lung and Premature Birth

Lucia J. Smith et al.

PAEDIATRIC RESPIRATORY REVIEWS (2010)

Article Physiology

Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection

Stephan W. Glasser et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)

Article Physiology

Respiratory syncytial virus infection alters surfactant protein A expression in human pulmonary epithelial cells by reducing translation efficiency

Shirley R. Bruce et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)

Article Anatomy & Morphology

A Recombinant Fragment of Human Surfactant Protein D Lacking the Short Collagen-Like Stalk Fails to Correct Morphological Alterations in Lungs of SP-D Deficient Mice

Lars Knudsen et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Environmental tobacco smoke effects on lung surfactant film organization

Patrick C. Stenger et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

Article Biochemistry & Molecular Biology

Kinematic viscosity of therapeutic pulmonary surfactants with added polymers

Karen W. Lu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

Review Medicine, Research & Experimental

Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) gene regulation in the lung

Vijay Boggaram

CLINICAL SCIENCE (2009)

Article Cardiac & Cardiovascular Systems

Surfactant as salvage therapy in life threatening primary graft dysfunction in lung transplantation

Anat Amital et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2009)

Article Obstetrics & Gynecology

Animal-derived surfactants: where are we? The evidence from randomized, controlled clinical trials

R. Ramanathan

JOURNAL OF PERINATOLOGY (2009)

Article Obstetrics & Gynecology

Pulmonary surfactant kinetics of the newborn infant: novel insights from studies with stable isotopes

V. P. Carnielli et al.

JOURNAL OF PERINATOLOGY (2009)

Article Biochemistry & Molecular Biology

Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities

Albert van Dijk et al.

MOLECULAR IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

A comparative study of mechanisms of surfactant inhibition

Lasantha Gunasekara et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

Review Biochemistry & Molecular Biology

Current perspectives in pulmonary surfactant - Inhibition, enhancement and evaluation

Yi Y. Zuo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

Review Biochemistry & Molecular Biology

Structure of pulmonary surfactant membranes and films:: The role of proteins and lipid-protein interactions

Jesus Perez-Gil

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

Article Critical Care Medicine

Secretory phospholipase A2 and neonatal respiratory distress: pilot study on broncho-alveolar lavage

Daniele De Luca et al.

INTENSIVE CARE MEDICINE (2008)

Article Otorhinolaryngology

Intranasal phenylephrine-surfactant treatment is not beneficial in otitis media with effusion

Deborah Johnson et al.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2008)

Article Respiratory System

Characterization of nebulized liposomal amikacin (Arikace™) as a function of droplet size

Zhili Li et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2008)

Article Immunology

The Use of Surfactant in Lung Transplantation

Anat Amital et al.

TRANSPLANTATION (2008)

Article Pediatrics

Lung deposition after inhalation with various nebulisers in preterm infants

E. Koehler et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2008)

Article Otorhinolaryngology

Protective effect of pulmonary surfactant on cilia of Eustachian tube in otitis media with effusion

Zhaoxin Ma et al.

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2007)

Article Critical Care Medicine

Diffuse lung disease in young children - Application of a novel classification scheme

Gail H. Deutsch et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)

Article Ophthalmology

Detection of surfactant proteins A and D in human tear fluid and the human lacrimal system

Lars Braeuer et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2007)

Article Biochemistry & Molecular Biology

ABCA3 is critical for lamellar body biogenesis in vivo

Naeun Cheong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Targeted inactivation of the murine Abca3 gene leads to respiratory failure in newborns with defective lamellar bodies

Markus Hammel et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Physiology

Interactions of serum with lung surfactant extract in the bronchiolar and alveolar airway models

Kaushik Nag et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2007)

Review Physiology

Regulation of surfactant secretion in alveolar type II cells

Alexandra V. Andreeva et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

ABCA3-mediated choline-phospholipids uptake into intracellular vesicles in A549 cells

Yoshihiro Matsumura et al.

FEBS LETTERS (2007)

Article Biochemistry & Molecular Biology

LIPID MAPS online tools for lipid research

Eoin Fahy et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Cardiac & Cardiovascular Systems

Effects of exogenous surfactant instillation in clinical lung transplantation:: A prospective, randomized trial

Martin Strueber et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2007)

Article Biochemistry & Molecular Biology

ABCA3 as a lipid transporter in pulmonary surfactant biogenesis

Nobuhiro Ban et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Differential effect of surfactant and its saturated phosphatidylcholines on human blood macrophages

Christian Gille et al.

JOURNAL OF LIPID RESEARCH (2007)

Article Chemistry, Multidisciplinary

Condensing effect of palmitic acid on DPPC in mixed Langmuir monolayers

Gang Ma et al.

LANGMUIR (2007)

Article Cell Biology

Expression of ABCA3 in developing lung and other tissues

Mildred T. Stahlman et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2007)

Review Obstetrics & Gynecology

Surfactant protein polymorphisms and neonatal lung disease

Mikko Hallman et al.

SEMINARS IN PERINATOLOGY (2006)

Article Biochemistry & Molecular Biology

Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency

Yoshihiro Matsumura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Critical Care Medicine

Alteration of the pulmonary surfactant system in full-term infants with hereditary ABCA3 deficiency

Frank Brasch et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

Review Critical Care Medicine

The future of surfactant therapy during ALI/ARDS

James F. Lewis et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

Article Critical Care Medicine

Intratracheal recombinant surfactant protein D prevents endotoxin shock in the newborn preterm lamb

M Ikegami et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

Article Biochemistry & Molecular Biology

Oxidative damage to surfactant protein D in pulmonary diseases

V Starosta et al.

FREE RADICAL RESEARCH (2006)

Article Respiratory System

Surfactant catabolism

M Ikegami

RESPIROLOGY (2006)

Article Biochemistry & Molecular Biology

Lysophospholipid and fatty acid inhibition of pulmonary surfactant:: Non-enzymatic models of phospholipase A2 surfactant hydrolysis

RD Hite et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2005)

Article Respiratory System

Mechanisms responsible for surfactant changes in sepsis-induced lung injury

W Huang et al.

EUROPEAN RESPIRATORY JOURNAL (2005)

Review Biochemistry & Molecular Biology

Acute lung injury and the acute respiratory distress syndrome - Four decades of inquiry into pathogenesis and rational management

MA Matthay et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2005)

Article Pediatrics

Aerosol deposition in neonatal ventilation

JC Dubus et al.

PEDIATRIC RESEARCH (2005)

Article Physiology

Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes

JW Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)

Article Physiology

Lysophospholipid generation and phosphatidylglycerol depletion in phospholipase A2-mediated surfactant dysfunction

RD Hite et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)

Article Pediatrics

A common mutation in the surfactant protein C gene associated with lung disease

HS Cameron et al.

JOURNAL OF PEDIATRICS (2005)

Article Physiology

Naturally derived commercial surfactants differ in composition of surfactant lipids and in surface viscosity

M Rüdiger et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)

Article Biochemistry & Molecular Biology

Processing of pulmonary surfactant protein B by napsin and cathepsin H

T Ueno et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Respiratory System

Lysosomal cysteine proteases in the lung:: role in protein processing and immunoregulation

F Bühling et al.

EUROPEAN RESPIRATORY JOURNAL (2004)

Article Medicine, Research & Experimental

Otitis media: Treatment with intranasal aerosolized surfactant

SS Chandrasekhar et al.

LARYNGOSCOPE (2004)

Article Critical Care Medicine

The number of alveoli in the human lung

M Ochs et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)

Article Pediatrics

The laryngeal mask airway: potential applications in neonates

D Trevisanuto et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2004)

Article Biochemistry & Molecular Biology

Surfactant lipid peroxidation damages surfactant protein A and inhibits interactions with phospholipid vesicles

AI Kuzmenko et al.

JOURNAL OF LIPID RESEARCH (2004)

Article Physiology

Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome

A Ishizaka et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2004)

Article Critical Care Medicine

Surfactant protein-A and phosphatidylglycerol suppress type IIA phospholipase A2 synthesis via nuclear factor-κB

YZ Wu et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)

Article Physiology

SP-B deficiency causes respiratory failure in adult mice

KR Melton et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2003)

Article Biochemistry & Molecular Biology

In vitro surfactant protein B deficiency inhibits lamellar body formation

CD Foster et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2003)

Article Physiology

Pulmonary surfactant: The key to the evolution of air breathing

CB Daniels et al.

NEWS IN PHYSIOLOGICAL SCIENCES (2003)

Review Medicine, General & Internal

Mechanisms of disease: Hydrophobic surfactant proteins in lung function and disease

JA Whitsett et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Review Biochemistry & Molecular Biology

Pulmonary surfactant: phase behavior and function

B Piknova et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2002)

Article Pharmacology & Pharmacy

Intratracheal administration of glucocorticoids using surfactant as a vehicle

AJ Nimmo et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2002)

Article Critical Care Medicine

Surfactant synthesis and kinetics in infants with congenital diaphragmatic hernia

PE Cogo et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)

Article Biochemistry & Molecular Biology

Abnormal expression of surfactant protein C and lung disease

LM Nogee

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2002)

Article Physiology

Bulk shear viscosities of endogenous and exogenous lung surfactants

DM King et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2002)

Article Biochemistry & Molecular Biology

Intracellular and intraalveolar localization of surfactant protein a (SP-A) in the parenchymal region of the human lung

M Ochs et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2002)

Article Respiratory System

Evaluation of alveolar surfactant aggregates in vitro and in vivo

AM Brackenbury et al.

EUROPEAN RESPIRATORY JOURNAL (2002)

Article Respiratory System

Surfactant replacement for ventilator-associated pneumonia: A preliminary report

RP Baughman et al.

RESPIRATION (2002)

Article Biochemistry & Molecular Biology

Phosphatidylcholine molecular species in lung surfactant - Composition in relation to respiratory rate and lung development

W Bernhard et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2001)

Article Critical Care Medicine

Surfactant and corticosteroid effects on lung function in a rat model of acute lung injury

CM Chen et al.

CRITICAL CARE MEDICINE (2001)

Article Biophysics

Interaction of lung surfactant proteins with anionic phospholipids

DY Takamoto et al.

BIOPHYSICAL JOURNAL (2001)

Article Biochemistry & Molecular Biology

Concentration-dependent, temperature-dependent non-Newtonian viscosity of lung surfactant dispersions

DM King et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2001)

Article Pediatrics

Surfactant protein deficiency in familial interstitial lung disease

RS Amin et al.

JOURNAL OF PEDIATRICS (2001)

Article Biochemistry & Molecular Biology

Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure

LQ Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Physiology

Macrophage and type II cell catabolism of SP-A and saturated phosphatidylcholine in mouse lungs

O Gurel et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2001)

Article Multidisciplinary Sciences

Altered stability of pulmonary surfactant in SP-C-deficient mice

SW Glasser et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Pulmonary surfactant phosphatidylcholine transport bypasses the brefeldin A sensitive compartment of alveolar type II cells

K Osanai et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2001)

Article Critical Care Medicine

Endogenous surfactant turnover in preterm infants with respiratory distress syndrome studied with stable isotope lipids

P Cavicchioli et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

Review Physiology

Functions of surfactant proteins B and C

TE Weaver et al.

ANNUAL REVIEW OF PHYSIOLOGY (2001)

Review Respiratory System

Surfactant alteration and replacement in acute respiratory distress syndrome

A Gunther et al.

RESPIRATORY RESEARCH (2001)

Review Respiratory System

Alveolar epithelial type II cell: defender of the alveolus revisited

H Fehrenbach

RESPIRATORY RESEARCH (2001)

Article Critical Care Medicine

Exogenous surfactant supplementation in infants with respiratory syncytial virus bronchiolitis

SM Tibby et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

Article Critical Care Medicine

Commercial versus native surfactants - Surface activity, molecular components, and the effect of calcium

W Bernhard et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

Article Physiology

Distinct changes in pulmonary surfactant homeostasis in common β-chain-and GM-CSF-deficient mice

JA Reed et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2000)

Article Critical Care Medicine

Exogenous surfactant kinetics in infant respiratory distress syndrome: A novel method with stable isotopes

M Torresin et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

Article Biochemistry & Molecular Biology

Pulmonary surfactant metabolism in infants lacking surfactant protein B

MF Beers et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2000)

Article Physiology

Effect of budesonide and salbutamol on surfactant properties

D Palmer et al.

JOURNAL OF APPLIED PHYSIOLOGY (2000)

Article Biochemistry & Molecular Biology

Degree of lung maturity determines the direction of the interleukin-1-induced effect on the expression of surfactant proteins

V Glumoff et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2000)

Article Chemistry, Multidisciplinary

Drug solubilization in lung surfactant

TS Wiedmann et al.

JOURNAL OF CONTROLLED RELEASE (2000)

Article Physiology

Surfactant metabolism in SP-D gene-targeted mice

M Ikegami et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2000)