Related references
Note: Only part of the references are listed.Functional evaluation of 16SCHADmissense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro
Kelly Velasco et al.
JOURNAL OF INHERITED METABOLIC DISEASE (2021)
Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology
Christina Dimovasili et al.
JOURNAL OF NEUROCHEMISTRY (2021)
Canagliflozin impairs blood reperfusion of ischaemic lower limb partially by inhibiting the retention and paracrine function of bone marrow derived mesenchymal stem cells
Yinuo Lin et al.
EBIOMEDICINE (2020)
Allosteric regulation of glutamate dehydrogenase deamination activity
Soumen Bera et al.
SCIENTIFIC REPORTS (2020)
Multidisciplinary approach in medicine: successful pregnancy in a patient with hyperinsulinism/hyperammonaemia (HI/HA) syndrome
Bernadette J. M. Benner et al.
BMJ CASE REPORTS (2020)
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
Huai-Qiang Ju et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase
Karolina Luczkowska et al.
HUMAN GENOMICS (2020)
Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point
Hong Q. Smith et al.
NEUROCHEMICAL RESEARCH (2019)
Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes
Lambros Mathioudakis et al.
NEUROCHEMICAL RESEARCH (2019)
Beyond estrogen: advances in tissue selective estrogen complexes and selective estrogen receptor modulators
J. V. Pinkerton et al.
CLIMACTERIC (2019)
Isothermal titration calorimetry for characterization of recombinant proteins
Lina Baranauskiene et al.
CURRENT OPINION IN BIOTECHNOLOGY (2019)
The Genetic and Molecular Mechanisms of Congenital Hyperinsulinism
Sonya Galcheva et al.
FRONTIERS IN ENDOCRINOLOGY (2019)
Congenital Hyperinsulinemic Hypoglycemia and Hyperammonemia due to Pathogenic Variants in GLUD1
Kakali Roy et al.
INDIAN JOURNAL OF PEDIATRICS (2019)
Current and Emerging Agents for the Treatment of Hypoglycemia in Patients with Congenital Hyperinsulinism
Ana Paola De Cosio et al.
PEDIATRIC DRUGS (2019)
Dissecting the Antenna in Human Glutamate Dehydrogenase: Understanding Its Role in Subunit Communication and Allosteric Regulation
Zoe A. Hoffpauir et al.
BIOCHEMISTRY (2019)
α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development
Xiongjun Wang et al.
MOLECULAR CELL (2019)
Allosteric discrimination at the NADH/ADP regulatory site of glutamate dehydrogenase
Omneya M. Nassar et al.
PROTEIN SCIENCE (2019)
Propylselen inhibits cancer cell growth by targeting glutamate dehydrogenase at the NADP+ binding site
Wei Hou et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
Glutamate dehydrogenase: Structure of a hyperinsulinism mutant, corrections to the atomic model, and insights into a regulatory site
Omneya M. Nassar et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2019)
Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate
Tom H. Peeters et al.
CANCER & METABOLISM (2019)
High-speed, inline measurement of protein activity and inactivation processes by supercontinuum attenuation spectroscopy
Hanna Koch et al.
ANALYST (2019)
Ebselen Reversibly Inhibits Human Glutamate Dehydrogenase at the Catalytic Site
Yanhong Jin et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2018)
Chlorogenic acids inhibit glutamate dehydrogenase and decrease intracellular ATP levels in cultures of chick embryo retina cells
Ivan Domith et al.
BIOCHEMICAL PHARMACOLOGY (2018)
The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications
Chris Carrico et al.
CELL METABOLISM (2018)
A ternary complex model of Sirtuin4-NAD+ -Glutamate dehydrogenase
Yusuke Kato et al.
COMPUTATIONAL BIOLOGY AND CHEMISTRY (2018)
Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis
Melis Karaca et al.
DIABETES (2018)
Strategies for optimization of heterologous protein expression in E-coli: Roadblocks and reinforcements
Jashandeep Kaur et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)
Glutamate dehydrogenase: role in regulating metabolism and insulin release in pancreatic β-cells
David F. Wilson et al.
JOURNAL OF APPLIED PHYSIOLOGY (2018)
A new aggregation-induced emission fluorescent probe for rapid detection of nitroreductase and its application in living cells
Gaoping Xu et al.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2018)
Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect
Philipp F. Secker et al.
CELL DEATH & DISEASE (2018)
FITC-labeled D-glucose analog is suitable as a probe for detecting insulin-dependent glucose uptake
Lin Su et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
Target discovery of ebselen with a biotinylated probe
Zhenzhen Chen et al.
CHEMICAL COMMUNICATIONS (2018)
Clinical and Molecular Spectrum of Glutamate Dehydrogenase Gene Defects in 26 Chinese Congenital Hyperinsulinemia Patients
Chang Su et al.
JOURNAL OF DIABETES RESEARCH (2018)
Hepatic Encephalopathy and Astrocyte Senescence
Boris Goerg et al.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY (2018)
L-leucine stimulates glutamate dehydrogenase activity and glutamate synthesis by regulating mTORC1/SIRT4 pathway in pig liver
Tongxin Wang et al.
ANIMAL NUTRITION (2018)
Harnessing the Versatility of Optical Biosensors for Target-Based Small-Molecule Drug Discovery
Tim Kaminski et al.
ACS SENSORS (2017)
Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia
Mariagrazia Grimaldi et al.
HUMAN MOLECULAR GENETICS (2017)
Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic β-cells: A potential beneficial effect in the pre-diabetic state?
Shirin Pournourmohammadi et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)
Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators
Clint A. Stalnecker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Deproteinization is Necessary for the Accurate Determination of Ammonia Levels by Glutamate Dehydrogenase Assay in Blood Plasma From Subjects With Liver Injury
Melita Vodenicarovova et al.
LABORATORY MEDICINE (2017)
Extreme caution on the use of sirolimus for the congenital hyperinsulinism in infancy patient
Indraneel Banerjee et al.
ORPHANET JOURNAL OF RARE DISEASES (2017)
A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase
Mary Barrosse-Antle et al.
PEDIATRIC DIABETES (2017)
Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
Jessica B. Spinelli et al.
SCIENCE (2017)
Transcribing β-cell mitochondria in health and disease
Hindrik Mulder
MOLECULAR METABOLISM (2017)
Deproteinization is Necessary for the Accurate Determination of Ammonia Levels by Glutamate Dehydrogenase Assay in Blood Plasma From Subjects With Liver Injury
Melita Vodenicarovova et al.
LABORATORY MEDICINE (2017)
Strategies of codon optimization for high-level heterologous protein expression in microbial expression systems
Adnan B. Al-Hawash et al.
GENE REPORTS (2017)
Ebselen: Mechanisms of Glutamate Dehydrogenase and Glutaminase Enzyme Inhibition
Yan Yu et al.
ACS CHEMICAL BIOLOGY (2017)
Clinical practice guidelines for congenital hyperinsulinism
Tohru Yorifuji et al.
CLINICAL PEDIATRIC ENDOCRINOLOGY (2017)
Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor
Li Cheng et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
The Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease
Andreas Plaitakis et al.
BIOLOGY-BASEL (2017)
Biomolecular Interaction Assays Identified Dual Inhibitors of Glutaminase and Glutamate Dehydrogenase That Disrupt Mitochondrial Function and Prevent Growth of Cancer Cells
Min Zhu et al.
ANALYTICAL CHEMISTRY (2017)
Mono-sulfonated tetrazolium salt based NAD(P)H detection reagents suitable for dehydrogenase and real-time cell viability assays
Wei Zhang et al.
ANALYTICAL BIOCHEMISTRY (2016)
Cyanine-based 1-amino-1-deoxyglucose as fluorescent probes for glucose transporter mediated bioimaging
Hu Xu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Identification of a Novel Activator of Mammalian Glutamate Dehydrogenase
Hong Q. Smith et al.
BIOCHEMISTRY (2016)
The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice
Anders Molven et al.
DIABETES (2016)
A novel mutation in the glutamate dehydrogenase (GLUD1) of a patient with congenital hyperinsulinism-hyperammonemia (HI/HA)
Chen Fang et al.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2016)
Hyperinsulinism-hyperammonemia syndrome: a de novo mutation of the GLUD1 gene in twins and a review of the literature
Dorotea Ninkovic et al.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2016)
Binding Kinetics in Drug Discovery
Noelia Ferruz et al.
MOLECULAR INFORMATICS (2016)
Hyperinsulinism Hyperammonemia Syndrome, a Rare Clinical Constellation
Jonathan Hussain et al.
JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS (2016)
Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth
Lingtao Jin et al.
CANCER CELL (2015)
Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients
Gaojie Liu et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2015)
Interaction of Islet α-Cell and β-Cell in the Regulation of Glucose Homeostasis in HI/HA Syndrome Patients With the GDHH454Y Mutation
Guanghong Jia et al.
DIABETES (2014)
Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release
Richard G. Kibbey et al.
DIABETES (2014)
Glutamate Dehydrogenase Isoforms with N-Terminal (His)6- or FLAG-Tag Retain Their Kinetic Properties and Cellular Localization
Kamilla Pajecka et al.
NEUROCHEMICAL RESEARCH (2014)
Glutamate Dehydrogenase: Structure, Allosteric Regulation, and Role in Insulin Homeostasis
Ming Li et al.
NEUROCHEMICAL RESEARCH (2014)
Molecular mechanisms of protein induced hyperinsulinaemic hypoglycaemia
Suresh Chandran et al.
WORLD JOURNAL OF DIABETES (2014)
Clinical and molecular characterisation of 300 patients with congenital hyperinsulinism
Ritika R. Kapoor et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2013)
Glutamate dehydrogenase 1 and SIRT4 regulate glial development
Daniel Komlos et al.
GLIA (2013)
Inhibitors of Glutamate Dehydrogenase Block Sodium-Dependent Glutamate Uptake in Rat Brain Membranes
Brendan S. Whitelaw et al.
Frontiers in Endocrinology (2013)
The structure and allosteric regulation of mammalian glutamate dehydrogenase
Ming Li et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2012)
β-Cell-protective effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid as a glutamate dehydrogenase activator in db/db mice
Seung Jin Han et al.
JOURNAL OF ENDOCRINOLOGY (2012)
Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase
Laurene Vetterli et al.
MOLECULAR BIOLOGY OF THE CELL (2012)
Expression of human GLUD2 glutamate dehydrogenase in human tissues: Functional implications
Ioannis Zaganas et al.
NEUROCHEMISTRY INTERNATIONAL (2012)
The Role of Glutamate Dehydrogenase in Mammalian Ammonia Metabolism
Cleanthe Spanaki et al.
NEUROTOXICITY RESEARCH (2012)
Leucine-sensitive hyperinsulinaemic hypoglycaemia in patients with loss of function mutations in 3-Hydroxyacyl-CoA Dehydrogenase
Amanda J. Heslegrave et al.
ORPHANET JOURNAL OF RARE DISEASES (2012)
Syntheses of 2-NBDG analogues for monitoring stereoselective uptake of D-glucose
Toshihiro Yamamoto et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
The Complex Mechanism of Glutamate Dehydrogenase in Insulin Secretion
Leonard A. Fahien et al.
DIABETES (2011)
Epigallocatechin-3-O-gallate (EGCG) attenuates FFAs-induced peripheral insulin resistance through AMPK pathway and insulin signaling pathway in vivo
Yan Li et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2011)
Green Tea Polyphenols Control Dysregulated Glutamate Dehydrogenase in Transgenic Mice by Hijacking the ADP Activation Site
Changhong Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structural Basis for Leucine-induced Allosteric Activation of Glutamate Dehydrogenase
Takeo Tomita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Biosensor-based small molecule fragment screening with biolayer interferometry
Charles A. Wartchow et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2011)
The structure and allosteric regulation of glutamate dehydrogenase
Ming Li et al.
NEUROCHEMISTRY INTERNATIONAL (2011)
Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism/hyperammonemia syndrome
Jason R. Treberg et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)
Inhibitory effects of KHG26377 on glutamate dehydrogenase activity in cultured islets
Seung-Ju Yang et al.
BMB REPORTS (2010)
Mechanism of Hyperinsulinism in Short-chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency Involves Activation of Glutamate Dehydrogenase
Changhong Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Estrogen Modification of Human Glutamate Dehydrogenases Is Linked to Enzyme Activation State
Nikolas Borompokas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Novel Inhibitors Complexed with Glutamate Dehydrogenase ALLOSTERIC REGULATION BY CONTROL OF PROTEIN DYNAMICS
Ming Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
High throughput screening reveals several new classes of glutamate dehydrogenase inhibitors
Ming Li et al.
BIOCHEMISTRY (2007)
Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice
Changhong Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase
CH Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Unregulated insulin secretion by pancreatic beta cells in hyperinsulinism/hyperammonemia syndrome: Role of glutamate dehydrogenase, ATP-sensitive potassium channel, and nonselective cation channel
M Kawajiri et al.
PEDIATRIC RESEARCH (2006)
Uptake of a fluorescent deoxyglucose analog (2-NBDG) in tumor cells
RG O'Neil et al.
MOLECULAR IMAGING AND BIOLOGY (2005)
Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets
S Carobbio et al.
DIABETOLOGIA (2004)
Evolution of glutamate dehydrogenase regulation of insulin homeostasis is an example of molecular exaptation
A Allen et al.
BIOCHEMISTRY (2004)
Long-term follow-up of 114 patients with congenital hyperinsulinism
T Meissner et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2003)
Development and application of fluorescence polarization assays in drug discovery
TJ Burke et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2003)
Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation
S Banerjee et al.
BIOCHEMISTRY (2003)
Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUB1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine
I Zaganas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion - Identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydrogenase
Y Tanizawa et al.
DIABETES (2002)
Molecular characterisation of glutamate dehydrogenase gene defects in Japanese patients with congenital hyperinsulinism/hyperammonaemia
H Fujioka et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2001)
The inhibition of gluconeogenesis by chloroquine contributes to its hypoglycaemic action
R Jarzyna et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
Hyperinsulinism and hyperammonemia syndrome: Report of twelve unrelated patients
P De Lonlay et al.
PEDIATRIC RESEARCH (2001)
Hyperinsulinism/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase
C MacMullen et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2001)
Molecular basis and characterization of the hyperinsulinism/hyperammonemia syndrome - Predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene
CA Stanley et al.
DIABETES (2000)