4.6 Review

High-Intensity Focused Ultrasound in the Treatment of Breast Cancer

Journal

CURRENT MEDICINAL CHEMISTRY
Volume 28, Issue 25, Pages 5179-5188

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867327666201111143206

Keywords

High-intensity focused ultrasound; therapeutic ultrasound; ablation; image-guidance; non-invasive mo-dality; breast cancer

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High-intensity focused ultrasound (HIFU) is a non-invasive method of ablating malignant tumors, with growing interest in its clinical application for breast cancer treatment. Despite technical challenges and limited clinical studies, HIFU is considered safe and potentially the preferred treatment option for most breast cancer patients in the future.
High-intensity focused ultrasound (HIFU) is a non-invasive method of ablating malignant tumors. This paper will review the current clinical application of HIFU specially in the treatment of breast cancer. In addition to clinical studies, this review will also look into some basic studies that could address the technical issues related to this modality. In general, HIFU is considered to be safe being non-invasive and non-ionizing. The complication occurrence rate is low and repeated treatment is possible, making it an attractive option for some patients. However, for more than two decades since it was first used to treat breast cancer, clinical studies on HIFU still remain at the investigative stage and are only available in several centers. Reasons contributing to such few studies on HI FU include lack of specialized medical team and bioengineering technical staff, and breast cancer-dedicated imaging-HIFU platform to attain positive outcomes. Despite these circumstances, we believe that HIFU will eventually become the treatment of choice for most breast cancer patients in the near future.

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