Journal
CURRENT MEDICINAL CHEMISTRY
Volume 28, Issue 25, Pages 5034-5047Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867328666210617105209
Keywords
Cancer; interferon-induced protein; tetratricopeptide repeats; IFIT; biomarker; prognostic factor
Funding
- National Medical Research Council, Singapore [MOH-000152]
- Yong Loo Lin School of Medicine, National University of Singapore
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The IFIT family of proteins is crucial in the antiviral immune response, with recent research highlighting their significance in cancer. They have the potential to serve as cancer biomarkers and prognostic factors in various types of malignant neoplasms.
The Interferon-induced protein with tetratricopeptide repeats (IFIT) family is an important component of the antiviral immune response. There are currently four known IFIT family members in humans, namely IFIT1, IFIT2, IFIT3 and IFIT5. Recent discoveries have brought attention to the significant roles of IFITs in cancer. This review summarises current knowledge on the biological roles of different IFIT proteins in various types of malignant neoplasm, and highlights the potential use of these molecules as cancer biomarkers and prognostic factors.
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