Journal
CURRENT MEDICINAL CHEMISTRY
Volume 28, Issue 25, Pages 5066-5083Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867328666210629122238
Keywords
Syndecan; proteoglycan; breast cancer; prognosis; therapeutic target; prognostic marker; heparan sul-fate; extracellular matrix
Funding
- Deutsche Forschungsgemeinschaft DFG [GO1392/8-1]
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This review summarizes the current understanding of breast carcinogenesis in correlation with Syndecan-1 expression, the mechanisms involved, and proposed therapeutic strategies against Syndecan-1-related malignancy.
The successive stages of breast cancer growth and dissemination depend on cell-autonomous factors and the communication between tumor cells and their surrounding cellular and extracellular matrix microenvironment. The cell surface heparan sulfate proteoglycan Syndecan-1 is dysregulated both in tumor cells and cells of the breast tumor stroma, indicating a potential role in the pathogenesis of this most frequent malignancy in women. Indeed, Syndecan-1 interacts with numerous ligands and receptors relevant to tumor progression, affecting processes as diverse as cancer stem cell function, cell proliferation, apoptosis, cell adhesion, migration and invasion, tumor angiogenesis, and leukocyte function in the tumor stroma. The present review summarizes the current understanding of breast carcinogenesis in correlation with their Syndecan-1 expression, involved mechanisms, and proposed therapeutic strategies against Syndecan-1-related malignancy.
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