Journal
CURRENT DRUG METABOLISM
Volume 22, Issue 8, Pages 645-656Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389200222666210701164945
Keywords
Chloro-s-triazines; biotransformation; metabolites; toxicity; human exposure; regulatory guidance
Funding
- European Union's Horizon 2020 research and innovation programme [825762-EDCMET]
- Thule Institute, University of Oulu, Finland
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Chloro-s-triazines such as atrazine, cyanazine, propazine, simazine, and terbuthylazine are structurally similar herbicides with similar toxicokinetics. By comparing their characteristics, useful structure-activity relationships can be identified to enhance toxicological risk assessment for humans and ecosystems.
Chloro-s-triazines-atrazine, cyanazine, propazine, simazine, and terbuthylazine-are structurally similar herbicides, differing only in specific s-triazine4-and 6-N alkyl substituents. It is generally regarded that their toxicokinetics, such as, metabolic pathways, biological effects and toxicities, also share more similar features than the differences. Consequently, it is useful to compare their characteristics to potentially find useful structure-activity relationships or other similarities or differences regarding different active compounds, their metabolites, and biological effects including toxic outcomes. The ultimate goal of these exercises is to apply the summarized knowledge-as far as it is possible regarding a patchy and often inadequate database-to cross the in vitro -in vivo and animal-human borders and integrate the available data to enhance toxicological risk assessment for the benefit of humans and ecosystems.
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