Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 163, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2021.103365
Keywords
SARS-CoV-2; COVID-19; Cancer; Tumor; Mortality; Lung cancer; Breast cancer
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A systematic review and meta-analysis found that adult patients with solid or hematological malignancies and SARS-CoV-2 infection have a high probability of mortality, with lung cancer patients having a higher case fatality rate (CFR) and breast cancer patients having a lower CFR.
Background: A systematic review and meta-analysis was performed to estimate mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection. Methods: A systematic search of PubMed, up to 31 January 2021, identified publications reporting the casefatality rate (CFR) among adult patients with solid or hematological malignancies and SARS-CoV-2 infection. The CFR, defined as the rate of death in this population, was assessed with a random effect model; 95% confidence intervals (CI) were calculated. Results: Among 135 selected studies (N = 33,879 patients), the CFR was 25.4% (95% CI 22.9%-28.2%). At a sensitivity analysis including studies with at least 100 patients, the CFR was 21.9% (95% CI 19.1%-25.1%). Among COVID-19 patients with lung (N = 1,135) and breast (N = 1,296) cancers, CFR were 32.4% (95% CI 26.5%-39.6%) and 14.2% (95% CI 9.3%-21.8%), respectively. Conclusions: Patients with solid or hematological malignancies and SARS-CoV-2 infection have a high probability of mortality, with comparatively higher and lower CFRs in patients with lung and breast cancers, respectively.
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