Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 163, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2021.103368
Keywords
Hematopoietic stem cells; Niche; Microenvironment; Two-photon laser scanning microscopy
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Funding
- Instituto Serrapilheira/Serra [170815285]
- Proreitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG)
- CNPQ [405977/20182]
- National Institute of Science and Technology in Theranostics and Nanobiotechnology (CNPq/CAPES/FAPEMIG) [465669/20140]
- FAPEMIG [Rede Mineira de Engenharia de Tecidos e Terapia Celular (REMETTEC)] [RED0057016]
- FAPEMIG [Rede De Pesquisa Em Doencas Infecciosas Humanas E Animais Do Estado De Minas Gerais] [RED0031316]
- National Council for Scientific and Technological Development (CNPq)
- National Institute of Health [1R01CA179072-01A1]
- American Cancer Society Mentored Research Scholar grant [124443MRSG1312101CDD]
- CAPES
- postdoctoral fellowship (PNPD) from CAPES
- CNPq
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Recent studies using advanced technologies have successfully visualized endogenous hematopoietic stem cells in live animals, revealing that quiescent stem cells are more mobile than previously thought. This new understanding is crucial for research on hematopoietic stem cells and the treatment of various hematological diseases.
Hematopoietic stem cells are the most illustrious inhabitants of the bone marrow. Direct visualization of endogenous hematopoietic stem cells in this niche is essential to study their functions. Until recently this was not possible in live animals. Recent studies, using state-of-the-art technologies, including sophisticated in vivo inducible genetic approaches in combination with two-photon laser scanning microscopy, allow the follow-up of endogenous hematopoietic stem cells' behavior in their habitat. Strikingly, the new findings reveal that quiescent hematopoietic stem cells are more mobile than previously thought, and link their retained steady state within the niche to a mobile behavior. The arising knowledge from this research will be critical for the therapy of several hematological diseases. Here, we review recent progress in our understanding of hematopoietic stem cell biology in their niches.
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