Enhancement of bioavailability and bioactivity of diet-derived flavonoids by application of nanotechnology: a review

Flavonoids, which are a class of polyphenols widely existing in food and medicine, have enormous pharmacological effects. The functional properties of flavonoids are mainly distributed to their anti-oxidative, anticancer, and anti-inflammatoryeffects, etc. However, flavonoids' low bioavailability limits their clinical application, which is closely related to their intestinal absorption and metabolism. In addition, because of the short residence time of oral bioactive molecules in the stomach, low permeability and low solubility in the gastrointestinal tract, flavonoids are easy to be decomposed by the external environment and gastrointestinal tract after digestion. To tackle these obstacles, technological approaches like microencapsulation have been developed and applied for the formulation of flavonoid-enriched food products. In the light of these scientific advances, the objective of this review is to establish the structural requirements of flavonoids for appreciable anticancer, anti-inflammatory, and antioxidant effects, and elucidate a comprehensive mechanism that can explain their activity. Furthermore, the novelty in application of nanotechnology for the safe delivery of flavonoids in food matrices is discussed. After a literature on the flavonoids and their health attributes, the encapsulation methods and the coating materials are presented.

Automated summary

Flavonoids, a class of widely existing polyphenols in food and medicine, have various pharmacological effects such as anti-oxidative, anticancer, and anti-inflammatory effects. However, their low bioavailability limits their clinical application, which is related to their intestinal absorption and metabolism. This review aims to establish the structural requirements of flavonoids for notable anticancer, anti-inflammatory, and antioxidant effects, and discuss the use of nanotechnology for safe delivery of flavonoids in food matrices.