Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 62, Issue 31, Pages 8646-8674Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2021.1931023
Keywords
Zebrafish; animal model; bioactive compounds; health benefits; safety assessment
Categories
Funding
- Technology Innovation RAMP
- D Project of Chengdu, China [2019YF0500117SN]
- National Key RAMP
- D Program of China [2018YFC1604405]
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Zebrafish, a popular freshwater fish in aquariums and laboratories, has emerged as a valuable tool for rapidly screening safe and effective substances from natural products. With the ability to assess bioactivity and safety of natural products, zebrafish models show promising potential in discovering novel natural products with potential health benefits.
The zebrafish is a species of freshwater fish, popular in aquariums and laboratories. Several advantageous features have facilitated zebrafish to be extensively utilized as a valuable vertebrate model in the lab. It has been well-recognized that natural products possess multiple health benefits for humans. With the increasing demand for natural products in the development of functional foods, nutraceuticals, and natural cosmetics, the zebrafish has emerged as an unprecedented tool for rapidly and economically screening and identifying safe and effective substances from natural products. This review first summarized the key factors for the management of zebrafish in the laboratory, followed by highlighting the current progress on the establishment and applications of zebrafish models in the bioactivity evaluation of natural products. In addition, the zebrafish models used for assessing the potential toxicity or health risks of natural products were involved as well. Overall, this review indicates that zebrafish are promising animal models for the bioactivity and safety evaluation of natural products, and zebrafish models can accelerate the discovery of novel natural products with potential health functions.
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