Journal
COMPUTERS IN BIOLOGY AND MEDICINE
Volume 135, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2021.104563
Keywords
Cytomegalovirus; Immunotherapeutic; Therapeutics; siRNA; miRNA; Database
Categories
Funding
- Key Research Area Grant of the Ministry of Science and Technologyof China [2016YFA0501703]
- National Science Foundation of China [32070662, 61832019, 32030063]
- Science and Technology Commission of Shanghai Municipality [19430750600]
- Natural Science Foundation of Henan Province [162300410060]
- SJTU JiRLMDS Joint Research Fund
- Medical and Engineering and Scientific Research at Shanghai Jiao Tong University [YG2017ZD14]
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This study evaluated the genomes and proteomes of different CMV species and developed an open-access platform, providing researchers with species-specific information to further explore CMV immune response and therapeutics.
Cytomegalovirus infection is a significant health concern and need further exploration in immunologic response mechanisms during primary and reactivated CMV infection. In this work, we evaluated the whole genomes and proteomes of different CMV species and developed an integrated open-access platform, CytomegaloVirusDb, a multi-Omics knowledge database for Cytomegaloviruses. The resource is categorized into the main sections Genomics, Proteomics, Immune response, and Therapeutics,. The database is annotated with the list of all CMV species included in the study, and available information is freely accessible at http://www.cmvdb. dqweilab-sjtu.com/index.php. Various parameters used in the analysis for each section were primarily based on the whole genome or proteome of each specie. The platform provided datasets are open to access for researchers to obtain CMV species-specific information. This will help further to explore the dynamics of CMVspecific immune response and therapeutics. This platform is a useful resource to aid in advancing research against Cytomegaloviruses.
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