Journal
COMPUTERS & MATHEMATICS WITH APPLICATIONS
Volume 92, Issue -, Pages 134-148Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.camwa.2021.03.025
Keywords
Partition coefficient; Drug penetration; Multiscale; Drug delivery; Nanoparticle; Biological tissue
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Funding
- Indian Institute of Technology Guwahati, India
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This study developed a multiscale method to improve drug delivery systems and analyzed the tissue penetration efficacy of drug nanoparticles through numerical experiments. The results showed that the partition phenomenon and particle size are important factors affecting the tissue penetration efficacy of nanoparticles.
This study aims to develop a multiscale method that will help improve drug delivery systems. A finite volume heterogeneous multiscale method (FV-HMM) is propounded to model mass transport by considering cell scale heterogeneity in the biological tissues. The partition phenomenon is included in the mass transport model. A new upscaling technique has been devised to evaluate the effective mass transport at the macro level. An interface method based on alternating direction implicit scheme is used to solve the microscale models. FV-HMM is used to study the tissue penetration efficacy of drug nanoparticles. Numerical experiments are performed with different parameters, and it is concluded that partition phenomenon and particle size are the important factors on tissue penetration efficacy of nanoparticles in drug delivery. Also, FV-HMM is used to determine the biological cell geometry impact on drug penetration at the tissue scale.
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