Journal
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
Volume 76, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2021.101646
Keywords
West Nile virus; Serology; Human; Bird; Virus neutralization test; Morocco
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Funding
- Institut Pasteur of Morocco
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The study found a significant seroprevalence of anti-WNV antibodies in humans and birds in northwest Morocco, indicating active circulation and exposure to the virus in these populations.
West Nile virus (WNV) was recently detected in Culex pipiens mosquitoes in Morocco. The aim of this study was to evaluate the seroprevalence of WNV in humans and in domestic birds in two regions of Morocco by the detection of IgG antibodies. Blood samples were obtained from 91 human patients and 92 domestic birds from September to December 2019. All study samples were tested using competitive enzyme-linked immunosorbent assay (cELISA) and WNV neutralization tests (VNT) were performed on positive sera. Of all samples, 4 (4.39 %) humans and 4 (4.34 %) birds were found to be seropositive for flaviviruses by the cELISA test. The VNT revealed that three of the four human samples detected positive by cELISA contained neutralizing antibodies against WNV. Two bird samples were confirmed positive by VNT. These results show a significant seroprevalence of antiWNV antibodies and therefore suggest the active circulation and exposure of human and bird populations in the northwest of Morocco.
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