Journal
EXPERT REVIEW OF PROTEOMICS
Volume 13, Issue 4, Pages 355-365Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.2016.1155986
Keywords
Clinical microbiology; Genetic heterogeneity; Comparative proteomics; Pan-proteomics; Bacterial strains; Microbiology; Bioinformatics
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Funding
- Queensland University of Technology Institute of Health and Biomedical Innovation Early Career Researcher Grant
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The comparison of proteomes between genetically heterogeneous bacterial strains may offer valuable insights into physiological diversity and function, particularly where such variation aids in the survival and virulence of clinically-relevant strains. However, reports of such comparisons frequently fail to account for underlying genetic variance. As a consequence, the current knowledge regarding bacterial physiological diversity at the protein level may be incomplete or inaccurate. To address this, greater consideration must be given to the impact of genetic heterogeneity on proteome comparisons. This may be possible through the use of pan-proteomics, an analytical concept that permits the ability to qualitatively and quantitatively compare the proteomes of genetically heterogeneous organisms. Limited examples of this emerging technology highlight currently unmet analytical challenges. In this article we define pan-proteomics, where its value lies in microbiology, and discuss the technical considerations critical to its successful execution and potential future application.
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