Journal
EXPERT REVIEW OF PROTEOMICS
Volume 13, Issue 9, Pages 873-881Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14789450.2016.1220837
Keywords
Proteomics; traditional Chinese medicine; TCM syndrome; acupuncture; herbal medicine; differentially expressed protein; system biology
Categories
Funding
- National Natural Science Foundation of China [81573826]
- National Basic Research Program of China [2014CB542902]
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Introduction: Traditional Chinese medicine (TCM) is a widely used complementary alternative medicine approach. Although many aspects of its effectiveness have been approved clinically, rigorous scientific techniques are highly required to translate the promises from TCM into powerful modern therapies. In this respect, proteomics is useful because of its ability to unveil the underlying target proteins and/or protein biomarkers.Areas covered: In this review, we summarize the recent interplay between proteomics and research on TCM, ranging from exploration of the medicinal materials to the biological basis of TCM concepts, and from pathological studies to pharmacological investigations. We show that proteomic analyses provide preliminary biological evidence of the promises in TCM, and the integration of proteomics with other omics and bioinformatics offers a comprehensive methodology to address the complications of TCM.Expert commentary: Currently, only limited information can be obtained regarding TCM issues and thus more work is required to resolve the ambiguity. As such, more collaborations between proteomics and other techniques (other omics, network pharmacology, etc.) are essential for deciphering the underlying biological basis in TCM topics.
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