4.7 Article

Exosome-based hybrid nanostructures for enhanced tumor targeting and hyperthermia therapy

Journal

COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 205, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.colsurfb.2021.111915

Keywords

Exosome; Folic acid; Magnetic nanoparticles; Hyperthermia; Combined cancer therapy

Funding

  1. Korea Health Technology Development R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI19C0642]
  2. DGIST R&D Program of the Ministry of Science and ICT [21-RT-01]

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The study introduces an exosome-based hybrid nanostructure with improved targeting ability and therapeutic efficacy against colorectal cancer. By utilizing exosomes as a carrier and adding a tumor-targeting ligand, the structure exhibits enhanced targeting performance. Through in vitro and in vivo experiments, it was found that the structure could induce increased apoptosis and effectively inhibit tumor growth.
Recently, natural exosomes have attracted attention as an ideal drug carrier to overcome the limitations of existing drug delivery systems which are toxicity induction and low cancer-targeting performance. In this study, we propose an exosome-based hybrid nanostructure (EHN) with improved targeting ability and therapeutic efficacy against colorectal cancer by using exosomes isolated from the tumor cell line as a drug carrier. The proposed EHN can have high biocompatibility by using exosomes, a biologically derived material, and show improved targeting performance by adding a tumor-targeting ligand (folic acid). In addition, the proposed EHN is capable of chemotherapy because doxorubicin, an anticancer drug, is encapsulated by the exosome with high efficiency, and it can induce hyperthermia therapy because of the magnetic nanoparticles (MNPs) attached to the surface of exosomes. Through in vitro and in vivo experiments using a xenograft tumor mouse model, it was confirmed that the proposed EHN could exhibit increased apoptosis and excellent tumor growth inhibition ability. Therefore, the proposed EHN is expected to overcome the limitations of existing drug delivery systems and be utilized as an effective drug delivery system in cancer treatment.

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