4.7 Article

Progress in the study of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) reversing multidrug resistance

Journal

COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 205, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.colsurfb.2021.111914

Keywords

Multidrug resistance; D-alpha-tocopherol polyethylene glycol 1000 succinate; P-glycoprotein; Nanodelivery system

Funding

  1. Major Research Project of Shandong Province, P.R.China [2018GSF118004]
  2. Shandong Provincial Major Science & Technology Innovation Project, P.R.China [2018CXGC1411]
  3. Major Basic Research Projects of Shandong Natural Science Foundation, P.R.China [ZR2018ZC0232]

Ask authors/readers for more resources

TPGS serves as a P-gp inhibitor and drug carrier with unique advantages in reversing multidrug resistance, making it a promising approach for cancer chemotherapy. The latest research on TPGS-based nanodelivery systems demonstrates its potential in preventing MDR and reducing toxic side effects in clinical applications.
Currently, multidrug resistance (MDR) is one of the major reasons for failure in clinical cancer chemotherapy. Overexpression of the ATP binding cassette (ABC) transporter P-glycoprotein (P-gp), which significantly increases the efflux of anticancer drugs from tumor cells, enhances MDR. In the past few decades, four generations of P-gp inhibitors have appeared. However, they are limited in clinical application due to their severe toxic side effects. As a P-gp inhibitor and carrier for loading chemotherapy agents, TPGS has received increasing attention due to its advantages and unique properties of reversing MDR. TPGS is an amphipathic agent that increases the solubility of most chemotherapy drugs and decreases severe side effects. In addition, TPGS is an excellent carrier with P-gp-inhibiting ability. In this review, we summarize the latest articles on TPGS-based nanodelivery systems to prevent MDR.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available