Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 205, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2021.111839
Keywords
Drug delivery; Drug resistant cancer; Mesoporous silica; Schiff base
Funding
- National Natural Science Foundation of China [U1703118]
- Natural Science Foundation of Jiangsu Province [BK20181364]
- Natural Science Foundation of Jiangsu Higher Ed-ucation Institutions of China [19KJA310003]
- Priority Academic Program Development of Jiangsu Higher Educa-tion Institutions (PAPD)
- Jiangsu Specially-Appointed Professor project, China
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The study synthesized CHO-SBA-15/DOX nanocomposite, utilizing acid-sensitive imine bonds for pH-responsive drug release, resulting in enhanced cytotoxic effect on DOX-resistant tumor cells and significantly reduced systemic toxicity in mice.
Multidrug resistance (MDR), evoked by improper chemotherapeutic practices, poses a serious threat to public health, which leads to increased medical burdens and weakened curative effects. Taking advantage of the enhanced pharmaceutical effect of Schiff base compounds, an aldehyde-modified mesoporous silica SBA-15 (CHO-SBA-15)-bonded anticancer drug combined with doxorubicin hydrochloride (DOX) was synthesized via a Schiff base reaction. Due to the acid-sensitive imine bonds formed between CHO-SBA-15 and DOX, the asprepared nanocomposites exhibited pH-responsive drug releasing behaviours, resulting in a more enhanced cytotoxic effect on DOX-resistant tumour cells than that of free drugs. Notably, the in vivo studies indicated that mice treated with CHO-SBA-15/DOX composites evidently showed more attenuated systemic toxicity than the free drug molecules. The siliceous mesopore Schiff base-bonded anticancer drug nanocomposite, with minimal chemical modifications, provides a simplified yet efficient therapeutic nanoplatform to deal with drug-resistant cancer.
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