Skin targeting of resveratrol-loaded starch-based Pickering emulsions: preparation, characterization, and evaluation

The present work aimed to prepare new starch-based Pickering emulsions for topical application of resveratrol. A sustainedrelease profile was observed for up to 12 h. Superior stability was achieved for 60 days at 4 degrees C and 25 degrees C compared to -20 degrees C and 40 degrees C. Good centrifugal stability and dilution stability were shown at different conditions. The entrapment efficiency (EE) was maintained at over 85% in various situations. DPPH radical scavenging study confirmed that resveratrol-loaded starch-based Pickering emulsions had a more conspicuous sustained-release effect on resveratrol, and the antioxidant capacities of resveratrol were not affected. Compared to the resveratrol ethanol solution, the resveratrol-loaded starch-based Pickering emulsions showed a higher ability to improve skin permeation of resveratrol and significantly enhanced the distribution of resveratrol in the skin as well. These studies demonstrated that starch-based resveratrol-loaded Pickering emulsions might be a promising drug delivery system for topical application of resveratrol.

Automated summary

The study demonstrated that starch-based resveratrol-loaded Pickering emulsions exhibit good sustained-release performance for topical application of resveratrol, with excellent stability and antioxidant capacity. They also showed a significant ability to enhance skin permeation and distribution of resveratrol compared to resveratrol ethanol solutions, making them a promising drug delivery system.