4.2 Article

Bringing Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging to the Clinics

Journal

CLINICS IN LABORATORY MEDICINE
Volume 41, Issue 2, Pages 309-324

Publisher

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cll.2021.03.009

Keywords

Mass spectrometry imaging; MALDI; Cancer; Infectious disease; Drug distribution; Clinical

Funding

  1. National Institutes of Health/National Cancer Institute (NIH/NCI) [R01CA201469, U54CA210180]
  2. Breast Cancer Research Foundation
  3. Ferenc Jolesz National Center for Image Guided Therapy at BWH [P41 EB015898]

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Mass spectrometry imaging is an emerging analytical technique that uses a mass spectrometer to analyze targets in at least two spatial dimensions while preserving the relative spatial location of molecules during analysis.
Mass spectrometry imaging (MSI) is an emerging set of analytical techniques that hold promise in changing pathology and tissue-based diagnostics.1 In its simplest sense, MSI is an analytical chemistry application in which a target is analyzed using a mass spectrometer in at least 2 spatial dimensions and, in doing so, preserves the relative spatial location of molecules during analysis. The net effect is the creation

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