Journal
CLINICAL TRANSPLANTATION
Volume 35, Issue 8, Pages -Publisher
WILEY
DOI: 10.1111/ctr.14375
Keywords
clinical trials; dual-energy X-ray absorptiometry; exercise training; osteoporosis; sarcopenia
Categories
Funding
- Division of Cardiovascular and Pulmonary Diseases at Oslo University Hospital
- Norwegian Respiratory Society
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High-intensity training after lung transplantation significantly improved trabecular bone score, but did not have a significant impact on physical activity, lean body mass, or bone mineral density.
Background Loss of bone mineral and skeletal muscle mass is common after lung transplantation (LTx), and physical activity (PA) may prevent further deterioration. We aimed to assess the effects of 20-week high-intensity training (HIT) on body composition, bone health, and PA in LTx recipients, 6-60 months after surgery. Methods In a randomized controlled trial, 51 LTx recipients underwent Dual-energy X-ray absorptiometry (DXA), and PA level and sedentary time were objectively recorded by accelerometers for seven consecutive days. Of these, 39 participants completed the study, including 19 participants in the HIT group and 20 participants in the standard care group. Results Following the intervention, ANCOVA models revealed a nonsignificant between-group difference for change in lean body mass (LBM) and bone mineral density (BMD) of the lumbar spine of 0.4% (95% CI = -3.2, 1.5) (p = .464) and 1.0% (95% CI=-1.3, 3.4) (p = .373), respectively. Trabecular bone score (TBS) of the lumbar spine (L1-L4), however, increased by 2.2 +/- 5.0% in the exercise group and decreased by -1.6 +/- 5.9% in the control group, giving a between-group difference of 3.8% (95% CI=0.1, 7.5) (p = .043). There were no between-group differences in PA or sedentary time. Conclusion High-intensity training after LTx improved TBS significantly, but not PA, LBM or BMD.
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