Journal
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
Volume 16, Issue 2, Pages 165-172Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737159.2016.1127758
Keywords
Circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); head and neck cancer (HNC); head and neck squamous cell carcinoma (HNSCC); human papillomavirus (HPV)
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Funding
- Queensland Centre for Head and Neck Cancer - Atlantic Philanthropies
- Queensland Government
- Princess Alexandra Hospital
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Head and neck cancer patients often present with advanced metastatic disease resulting in a poor 5-year survival. Therefore, there is a need for non-invasive diagnostic tools that could complement conventional imaging to inform clinicians of patient outcomes and treatment responses. A liquid biopsy addresses this unmet clinical need; a simple peripheral blood draw could provide information about the disseminated disease in terms of circulating tumor cells and circulating tumor DNA. Moreover, detectable tumor DNA in the saliva of head and neck cancer patients could signify the early signs of the disease and present an opportunity for clinical intervention. This review provides an overview of the current literature with regard to the feasibility of such a test in the head and neck cancer field and highlights the need for such a test.
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