Pharmacogene Variation Consortium: A Global Resource and Repository for Pharmacogene Variation

The Pharmacogene Variation Consortium (PharmVar) was founded in 2017 to provide the clinical and research communities a repository and standardized nomenclature of genes contributing to variability in drug metabolism and response. Over the past 4 years, PharmVar has provided the research and clinical pharmacogenetics/genomics communities with essential information for flagship pharmacogenes with well-established drug-gene relationships and published clinical guidelines such as CYP2C9, CYP2C19, and CYP2D6. In this Perspective we highlight recent milestones and standardization efforts.

Automated summary

PharmVar, founded in 2017, has provided the research and clinical pharmacogenetics/genomics communities with essential information on flagship pharmacogenes such as CYP2C9, CYP2C19, and CYP2D6 for the past four years. The consortium highlights recent milestones and standardization efforts in this Perspective.