Journal
CLINICAL NUCLEAR MEDICINE
Volume 46, Issue 12, Pages E603-E604Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLU.0000000000003767
Keywords
MSA-C; multiple system atrophy; brain PET/CT; I-123-ioflupane; atypical parkinsonism
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A 64-year-old female presented with urinary incontinence and neurological symptoms, showing hypometabolism of the whole cerebellum on imaging studies. Later, she developed tremor, postural instability, and ataxia, leading to a possible diagnosis of multiple system atrophy based on imaging and clinical symptoms.
We report a 64-year-old woman whose history started with urinary incontinence and neurological symptoms (cognitive impairment, dysarthria, and gait difficulties). The F-18-FDG PET/CT showed hypometabolism of the whole cerebellum. Then 6 months later, she developed tremor, postural instability, and ataxia, so she was hospitalized to complete study. Blood tests (antibodies, vitamin B12, copper, genetic test of spinocerebellar ataxia) did not have alterations, but imaging studies, along with clinical symptoms, provide the diagnosis of possible multiple system atrophy.
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