Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 13, Issue 3, Pages 223-233Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1744666X.2017.1243468
Keywords
Ulcerative colitis; anti TNF-; remission; mucosal healing; biosimilar; vedolizumab
Categories
Ask authors/readers for more resources
Introduction: Anti TNF- agents have become a significant advance in the management of ulcerative colitis, proving to induce, with rapid onset, clinical and endoscopic remission. However, there is still a considerable unmet medical need in ulcerative colitis.Areas covered: The aim of this review was to summarize the patterns of use and the effectiveness of anti TNF- in ulcerative colitis, highlighting their current position in treatment algorithms. Moreover, we set out a five-year view hypothesizing different treatment strategies.Expert commentary: The rapid onset of action and the effectiveness in inducing mucosal healing are the most important pros of anti TNF-, supporting present and future use. Conversely, the relevant risk of loss of response and the safety profile have raised several concerns. In the future, the advent of different molecular targeting therapies can improve the management of UC patients, evolving to individually tailored strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available