Journal
CLINICAL NEUROLOGY AND NEUROSURGERY
Volume 207, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.clineuro.2021.106791
Keywords
Parkinson's disease; Fecal microbiota transplant
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Funding
- Israel-America Foundation
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The study found that fecal microbiota transplant may be safe and effective in improving constipation, motor, and non-motor symptoms in Parkinson's disease patients. However, further research is needed to confirm these findings and assess long-term efficacy and safety, including through large scale randomized controlled trials.
Objective: We aimed to determine whether fecal microbiota transplant (FMT) is safe and possibly efficacious in treating constipation, motor, and non-motor symptoms in Parkinson's disease (PD) patients. Methods: Patients with PD, constipation and an indication for screening colonoscopy were treated with FMT. The study was conducted from December 2017 to November 2019, and clinical outcomes assessing motor, non-motor and constipation symptoms were compared at baseline (week 0) and at 2, 4, 8, 12, 16, 20, and 24 weeks after the FMT. Results: Six patients (3 men, age range 47-73, median age 52) were treated with FMT. Four weeks following the FMT, motor, non-motor and constipation scores were improved in 5 of 6 patients. At week 24, compared to before the FMT, the changes in motor scores ranged from - 13-7 points, in non-motor scores from - 2 to - 45 points, and in constipation scores from - 12-1 point. One patient had a serious adverse event requiring admission for observation only, and no adverse events were observed in all other patients. Conclusions: In this preliminary uncontrolled case series of 6 PD patients, a treatment with donor FMT infused via colonoscopy, was safe and resulted in improvement of PD motor and non-motor symptoms, including constipation, at 6 months. Further research is needed to assess longer-term maintenance of efficacy and safety, including in large scale randomized controlled trials. Trial registration: ClinicalTrials.gov - NCT03876327
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