Self-testing for the detection of SARS-CoV-2 infection with rapid antigen tests for people with suspected COVID-19 in the community

Article Multidisciplinary Sciences

Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening

Daniel B. Larremore et al.

Summary: The COVID-19 pandemic has led to a public health crisis due to the spread of SARS-CoV-2 through presymptomatic, symptomatic, and asymptomatic individuals. Effective population screening for the virus is essential for reopening societies and controlling its spread, with testing frequency and reporting speed playing crucial roles in its success. Test sensitivity is only marginally important compared to these factors.

SCIENCE ADVANCES (2021)

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News Item Multidisciplinary Sciences

Rapid coronavirus tests: a guide for the perplexed

Giorgia Guglielmi

Summary: Scientists are still debating whether millions of cheap, fast diagnostic kits will help control the pandemic.

NATURE (2021)

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Article Multidisciplinary Sciences

Estimating infectiousness throughout SARS-CoV-2 infection course

Terry C. Jones et al.

Summary: In a study of SARS-CoV-2 cases in Germany, it was found that younger subjects had lower viral loads but higher cell culture replication probabilities compared to older subjects. Additionally, 8% of subjects had viral loads above 10(9) copies per swab, with a third of them being presymptomatic, asymptomatic, or mildly symptomatic individuals with a mean age of 37.6 years. The B.1.1.7 lineage infections had a higher viral load and cell culture replication probability than non-B.1.1.7 subjects.

SCIENCE (2021)

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Article Medicine, General & Internal

Real-life validation of the Panbio™ COVID-19 antigen rapid test (Abbott) in community-dwelling subjects with symptoms of potential SARS-CoV-2 infection

Hendrik Gremmels et al.

Summary: The antigen rapid test showed high specificity and sensitivity in community-dwelling residents in the Netherlands and Aruba, especially when using a Ct value <32 cycles as the cut-off for RT-qPCR positivity. This test could play a significant role in controlling viral spread.

ECLINICALMEDICINE (2021)

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Article Infectious Diseases