4.7 Article

Association of E484K Spike Protein Mutation With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Vaccinated Persons: Maryland, January-May 2021

Journal

CLINICAL INFECTIOUS DISEASES
Volume 74, Issue 11, Pages 2053-2056

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciab762

Keywords

COVID-19; E484K; L452R; B; 1; 351; genomic surveillance

Funding

  1. National Institutes of Health Intramural Research Program

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A study in Maryland found that between January and May 2021, there was a higher prevalence of SARS-CoV-2 viruses carrying the spike protein mutation E484K among individuals infected after full vaccination against COVID-19.
Among 9048 people infected with SARS-CoV-2 between January and May 2021 in Maryland, in regression-adjusted analysis, SARS-CoV-2 viruses carrying the spike protein mutation E484K were disproportionately prevalent among persons infected after full vaccination against COVID-19 compared with infected persons who were not fully vaccinated (aOR, 1.96; 95% CI: 1.36-2.83).

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