Journal
CLINICAL INFECTIOUS DISEASES
Volume 73, Issue 7, Pages 1284-1287Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciab463
Keywords
transplant; antibiotic; donor; stewardship
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Funding
- Transplant Foundation's Innovative Research Grant Program, an affiliate of the Gift of Life Donor Program (Donation and Transplantation Grant)
- Antibacterial Resistance Leadership Group [5 UM 1AI104681-05]
- National Institutes of Health [K24-AI080942, K01-AI137317]
- Centers for Disease Control and Prevention (CDC) [CK16-004]
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The study found that a high percentage of deceased organ donors received antibiotics during their terminal hospitalization, with some potentially receiving redundant antibiotics, indicating a need for better stewardship in antibiotic use in this population.
Antibiotic use in deceased organ donors has not been previously described. In a retrospective cohort of 440 donors, we found 427 (97%) received at least one antibiotic course, 312 (71%) received broad-spectrum antibiotics, and 61 (14%) received potentially redundant antibiotics during their terminal hospitalization, suggesting a need for stewardship.
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