Journal
CLINICAL INFECTIOUS DISEASES
Volume 74, Issue 6, Pages 1089-1092Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciab581
Keywords
SARS-CoV-2; vaccine breakthrough; variants of concern; sequencing
Categories
Funding
- National Institutes of Health (ORIP) [S10OD028685]
- UW-Fred Hutch CFAR New Investigator Award [AI027757]
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Among 20 vaccine breakthrough cases at the institution, all infections were caused by variants of concern, with a median Ct value of 20.2. Variants of concern were significantly more prevalent in breakthrough infections compared to contemporaneous samples sequenced in the laboratory.
Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOCs) and had a median Ct of 20.2 (IQR, 17.1-23.3). When compared with 5174 contemporaneous samples sequenced in our laboratory, VOCs were significantly enriched among breakthrough infections (P < .05).
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