Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterized by systemic synovitis leading to joint destruction in which imbalances in pro-inflammatory and anti-inflammatory cytokines promote the induction of autoimmunity. Some pro-inflammatory cytokines can trigger the signaling pathways which responsible for immune-mediated inflammation in RA, and the activated signaling pathways produce pro-inflammatory cytokines, resulting in aggravation of RA. Hence, understanding of the signaling pathways and their inhibitors might be advantageous in the development of therapeutic targets and new drugs for RA. In the current review, we summarize the signaling pathways involved in the pathogenesis of RA as well as the potential role of specific inhibitors in its management. We hope this paper may serve a reference for future studies on signaling pathways implicated in the pathogenesis of RA and benefit the treatment of RA.

Automated summary

Rheumatoid arthritis is characterized by systemic synovitis and joint destruction due to imbalances in pro-inflammatory and anti-inflammatory cytokines. Understanding the signaling pathways and inhibitors is crucial for the development of therapeutic targets and new drugs for RA.