Journal
CLINICAL IMMUNOLOGY
Volume 230, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2021.108821
Keywords
Primary immunodeficiency disease; Inborn errors immunity; Children; COVID-19
Categories
Funding
- Plan Nacional de I+D+I [PI18/00223, FI19/00208, PI21/00211]
- ISCIII - Subdireccion General de Evaluacion y Fomento de la Investigacion Sanitaria
- Fondo Europeo de Desarrollo Regional (FEDER)
- Pla Estrategic de Recerca i Innovacio en Salut (PERIS)
- Departament de Salut, Generalitat de Catalunya [SLT006/17/00199]
- Leonardo Grant for Researchers and Cultural Creators
- BBVA Foundation [IN [17] _BBM_CLI_0357]
- Beca de Investigacion de la Sociedad Espanola de Inmunologia Clinica Alergologia y Asma Pediatrica
- Beca de Investigacion de la Sociedad Espanola de Inmunologia Clinica, Alergologia y Asma Pediatrica
- CERCA Programme/Generalitat de Catalunya
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The prevalence of COVID-19 in pediatric patients with moderate/severe IEI after the first wave was slightly higher than in the general population, but the majority of patients had a mild course, suggesting a potential protective factor related to age.
Background: Information regarding inborn error of immunity (IEI) as a risk factor for severe COVID-19 is scarce. We aimed to determine if paediatric patients with moderate/severe IEI got COVID-19 at the same level as the general population, and to describe COVID-19 expression. Material and methods: We included patients with moderate/severe IEI aged 0-21 years old: cross-sectional study (June2020) to determine the prevalence of COVID-19; prospective study (January2020-January2021) including IEI patients with COVID-19. Assays used: nasopharyngeal swab SARS-CoV-2 PCR and SARS-CoV-2-specific immunoglobulins. Results: Seven from sixty-five patients tested positive (prevalence: 10.7% (7%-13%)) after the first SARS-COV-2 wave and 13/15 patients diagnosed with COVID-19 had an asymptomatic/mild course. Conclusions: In our area, prevalence of COVID-19 in moderate/severe IEI paediatric patients after the first wave was slightly higher than in the general population. The majority of patients presented a benign course, suggesting a possible protective factor related with age despite IEI.
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