Journal
EXPERT REVIEW OF ANTICANCER THERAPY
Volume 16, Issue 3, Pages 359-371Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737140.2016.1143363
Keywords
cancer therapy; signal pathway; cell migration; prognostic marker; L1 cell adhesion molecule
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Funding
- National Natural Science Foundation of China [81201896, 81071884]
- National Health and Planning Commission of the PRC on General Surgery
- National Health and Planning Commission of the PRC on Oncology
- Research Fund for the Doctoral Program of Higher Education of China [20130071110052, 20110071110065]
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L1 cell adhesion molecule (L1CAM) is the prototype member of the L1-family of closely related neural adhesion molecules. L1CAM is differentially expressed in the normal nervous system as well as pathological tissues and displays a wide range of biological activities. In human malignancies, L1CAM plays a vital role in tumor growth, invasion and metastasis. Recently, increasing evidence has suggested that L1CAM exerts a variety of functions at different steps of tumor progression through a series of signaling pathways. In addition, L1CAM has been identified as a promising target for cancer therapy by using synthetic and natural inhibitors. In this review, we provide an up-to-date overview of the role of L1CAM involved in cancers and the rationale for L1CAM as a novel molecular target for cancer therapy.
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