Journal
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Volume 48, Issue 9, Pages 1224-1230Publisher
WILEY
DOI: 10.1111/1440-1681.13534
Keywords
gestational hypertension; hydrogen sulphide; nitrite; preeclampsia; pregnancy
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [2014-5/305587]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Sao Paulo Research Foundation [2015/20461-8, 2018/22767-5]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [15/20461-8] Funding Source: FAPESP
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This study measured plasma H2S levels in healthy pregnant women, gestational hypertensive patients, and preeclamptic patients. It found that H2S levels were elevated in preeclampsia and further increased in gestational hypertension, with a negative correlation with nitrite. This suggests that increased H2S may be a compensatory mechanism for reduced NO in hypertensive disorders of pregnancy.
Endothelial dysfunction is a hallmark of preeclampsia and the role of nitric oxide (NO) has been extensively studied in this pregnancy complication. In recent years, hydrogen sulphide (H2S) has arisen as a new gasotransmitter with an impact on endothelial function. However, the involvement of H2S in the pathophysiology of preeclampsia is not fully understood, and only a few studies with limited sample size have investigated circulating levels of H2S in preeclamptic patients. Moreover, H2S levels have not been previously evaluated in gestational hypertension. Furthermore, the relationship between H2S and NO in these hypertensive disorders of pregnancy has yet to be determined. We measured H2S levels in plasma of 120 healthy pregnant women, 88 gestational hypertensive and 62 preeclamptic women. We also measured plasma nitrite in a subset of patients and carried out correlation analysis between plasma H2S and nitrite in these three groups. We found that plasma H2S was elevated in preeclampsia and further increased in gestational hypertension compared to healthy pregnancy. Plasma nitrite was reduced in gestational hypertension and preeclampsia, and these levels were negatively correlated with H2S in both gestational hypertension and preeclampsia, but not in healthy pregnancy. Our results indicate that increases in H2S may represent a mechanism triggered as an attempt to compensate reduced NO in gestational hypertension and preeclampsia. Future studies are warranted to investigate the mechanisms underlying H2S/NO interaction on mediating endothelial dysfunction in these hypertensive disorders of pregnancy.
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