4.6 Article

FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma

Journal

CLINICAL AND EXPERIMENTAL MEDICINE
Volume 22, Issue 3, Pages 371-384

Publisher

SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10238-021-00760-6

Keywords

FURIN; Immune infiltration; Lung adenocarcinoma; SARS-CoV-2; Biomarker

Funding

  1. Guangdong Medical University [B2019016]
  2. Administration of Traditional Chinese Medicine of Guangdong Province [20201180, 20211223]
  3. Science and Technology Special Project of Zhanjiang [2019A01009]
  4. Basic and Applied Basic Research Program of Guangdong Province [2019A1515110201]
  5. Key Program of Marine Economy Development (Six Marine Industries) Special Foundation of Department of Natural Resources of Guangdong Province [GDNRC[2020] 038]
  6. Fund of Southern Marine Science and Engineering GuangdongLaboratory (Zhanjiang) [ZJW-2019-007]
  7. Discipline Construction Project of Guangdong Medical University [4SG21004G]

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FURIN is highly expressed in lung adenocarcinoma and significantly associated with poor overall survival, as well as correlated with immune cells and macrophage immune marker in LUAD patients. This suggests that FURIN could serve as a potential biomarker for prognosis and immune infiltration in LUAD patients.
FURIN, as a proprotein convertase, has been found to be expressed in a variety of cancers and plays an important role in cancer. In addition, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires FURIN to enter human cells. However, the role of FURIN in lung adenocarcinoma remains unclear. And the expression of SARS-CoV-2 related gene in lung adenocarcinoma has not been clarified. Therefore, in order to explore the prognostic value and mechanism of FURIN in lung adenocarcinoma, we performed bioinformatics analysis with Oncomine, Tumor Immune Estimation Resource, Gene Expression Profiling Interactive Analysis, human protein atlas, UALCAN, PrognoScan, Kaplan-Meier plotter, cBioPortal and LinkedOmics databases. And then we used GSE44274 in the GEO (Gene Expression Omnibus) database to analyze the expression of FURIN in LUAD patients who infected with SARS-CoV. FURIN was highly expressed in lung adenocarcinoma and was significantly associated with poor overall survival. FURIN expression was found to be correlated with six major permeable immune cells and with macrophage immune marker in LUAD patients. In addition, SARS-CoV-2 infection might affect the expression of FURIN. FURIN can be used as a promising biomarker for determining prognosis and immune infiltration in LUAD patients.

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