Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 206, Issue 2, Pages 226-236Publisher
OXFORD UNIV PRESS
DOI: 10.1111/cei.13658
Keywords
cytokines; dendritic cells; immunology; kidney transplantation; remote ischaemic conditioning
Categories
Funding
- Dansk Nefrologisk Selskab
- Lundbeckfonden
- Aarhus Universitetshospital
- Novo Nordisk Fonden
- Det Frie Forskningsrad
- Aarhus Universitet
- A.P. Moller og Hustru Chastine Mc-Kinney Mollers Fond til almene Formaal
- Sveriges Lakarforbund
- Nyreforeningen
- Institut for Klinisk Medicin, Aarhus Universitet
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The study investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors. The results showed no significant differences in immune cell and cytokine levels between the two groups, but both exhibited dynamic changes over time in response to the kidney transplantation and immunosuppression.
Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of delayed graft function and possibly reduce long-term graft survival. Remote ischaemic conditioning may protect against ischaemia/reperfusion injury and mitigate the immunological response to the graft. We investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors in the randomized CONTEXT study. Three circulating dendritic cell (DC) subtypes identified in peripheral blood from kidney transplant recipients [myeloid DCs, plasmacytoid DCs and immunoglobulin-like transcript (ILT)3(+) DCs] were measured at baseline, days 1, 3 and 5 and 1 and 3 months after transplantation. We also quantified 21 cytokines at baseline, days 1 and 5 and 3 months after transplantation. Neither DC counts nor cytokine levels differed between patients receiving remote ischaemic conditioning and controls; however, several parameters exhibited dynamic and parallel alterations in the two groups over time, reflecting the immunological response to the kidney transplantation and immunosuppression.
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