Journal
CLINICAL & TRANSLATIONAL ONCOLOGY
Volume 23, Issue 10, Pages 2046-2056Publisher
SPRINGER INT PUBL AG
DOI: 10.1007/s12094-021-02608-7
Keywords
Neuroendocrine tumour; Carcinoid syndrome; Resources; Costs; Somatostatin analogues
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Funding
- Ipsen
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This study shows that patients with uncontrolled carcinoid syndrome had more frequent emergency department visits, higher likelihood of hospital admission, longer hospital stays, and significantly higher hospitalization and emergency department costs compared to patients with controlled carcinoid syndrome. Better control of carcinoid syndrome may result in lower medical costs.
Purpose To report healthcare resource use and associated costs in controlled versus uncontrolled carcinoid syndrome (CS) in patients with neuroendocrine tumours. Methods A cross-sectional, non-interventional multicentre study was conducted with retrospective data analysis. Resource use was compared between two patient groups: those with controlled CS (> 12 months with no uncontrolled CS episodes) and uncontrolled CS (< 12 months since last uncontrolled episode). Patients were matched for age, sex, and origin and grade of tumour. When no matching patients were available, data from deceased patients were used. Information on healthcare resource use came from review of medical records, patient history and physician reports. Working capacity was assessed using the Work Productivity and Activity Impairment General Health questionnaire. Results Twenty-six university hospitals in Spain participated, between July 2017 and April 2018. 137 patients were enrolled; 104 were analysed (2 groups of 52). Patients with uncontrolled CS had 10 times more emergency department (ED) visits (mean 1.0 vs 0.10 visits; P = 0.0167), were more likely to have a hospital admission (40.4% vs 19.2%; P = 0.0116) and had longer hospital stays (mean 7.87 vs 2.10 days; P = 0.0178) than those with controlled CS. This corresponded to higher annual hospitalisation costs (mean euro5511.59 vs euro1457.22; P = 0.028) and ED costs (euro161.25 vs euro14.85; P = 0.0236). The mean annual total healthcare costs were 60.0% higher in patients with uncontrolled than controlled CS (P = NS). Conclusion This study quantifies higher health resource use, and higher hospitalisation and ED costs in patients with uncontrolled CS. Better control of CS may result 3in lower medical costs.
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