Arresting metastasis within the microcirculation

The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary beds, may add more complexity to CTCs journey towards metastasis. Revisiting how these mediators impact the ability of circulating tumour cells to survive and metastasise, will be vital to understand the role of microcirculation and advance our knowledge on metastasis.

Automated summary

The behavior of circulating tumor cells in the microcirculation is influenced by biomechanical adaptations and interactions with blood components, such as immune cells and platelets, adding complexity to their journey towards metastasis. Understanding how these mediators impact the survival and metastatic ability of circulating tumor cells is crucial for advancing knowledge on metastasis.