Journal
CHIRALITY
Volume 33, Issue 10, Pages 618-642Publisher
WILEY
DOI: 10.1002/chir.23344
Keywords
chiral amplification; chiral induction; chiral recognition; helix; peptide
Funding
- Science and Technology Innovation Commission of Shenzhen [JCYJ20180305124214580]
- Guangdong Provincial Department of Science and Technology [2019A1515110702, 2021A1515012569]
- Guangdong Academy of Science, GDAS Project of Science and Technology Development [2018GDASCX-0104, 2019GDASYL-0103025]
Ask authors/readers for more resources
Chirality is widespread in nature and can be deliberately designed in peptide-based materials to change physicochemical properties. Understanding the chiral effects is crucial for the development of novel materials in chemistry and biomedicine fields. The research explores chiral effects in affinity interaction, supramolecular structure formation, and applications in bioseparation, bioenrichment, cell incubation, protein aggregation inhibitors, chiral smart gels, and bionic electro devices.
Chirality is ubiquitous in nature with primary cellular functions that include construction of right-/left-handed helix and selective communications among diverse biomolecules. Of particularly intriguing are the chiral peptide-based materials that can be deliberately designed to change physicochemistry properties via tuning peptide sequences. Critically, understanding their chiral effects are fundamental for the development of novel materials in chemistry and biomedicine fields. Here, we review recent researches on chirality in peptide-based materials, summarizing relevant typical chiral effects towards recognition, amplification, and induction. Driven forces for the chiral discrimination in affinity interaction as well as the handedness preferences in supramolecular structure formation at both the macroscale and microscale are illustrated. The implementation of such chirality effects of artificial copolymers, assembled aggregates and their composites in the fields of bioseparation and bioenrichment, cell incubation, protein aggregation inhibitors, chiral smart gels, and bionic electro devices are also presented. At last, the challenges in these areas and possible directions are pointed out. The diversity of chiral roles in the origin of life and chirality design in different organic or composite systems as well as their applications in drug development and chirality detection in environmental protection are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available