Journal
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
Volume 27, Issue 8, Pages 621-625Publisher
SPRINGER
DOI: 10.1007/s11655-021-3300-2
Keywords
Weikang Capsule; magnetically controlled capsule endoscopy; enteric-coated aspirin; gastric mucosal injury; small intestinal mucosal injury; Chinese medicine
Categories
Funding
- Beijing Chinese Medicine Science and Technology Development Fund [JJ2018-02]
Ask authors/readers for more resources
The study investigated the effects of Weikang Capsule (WKC) on aspirin-related gastric and small intestinal mucosal injury by magnetically controlled capsule endoscopy (MCCE). The results showed that WKC can alleviate gastrointestinal symptoms, as well as gastric and duodenal mucosal injuries, in patients taking enteric-coated aspirin without aggravating jejunal or ileal mucosal injury, suggesting it may be an effective alternative treatment for these patients.
Objective: To investigate the effects of Weikang Capsule (WKC) on aspirin-related gastric and small intestinal mucosal injury by magnetically controlled capsule endoscopy (MCCE). Methods: Patients taking enteric-coated aspirin aged 40-75 years were enrolled in Beijing Anzhen Hospital, Capital Medical University from January 2019 to December 2019. The patients continued taking aspirin Tablet (100 mg per day) and underwent MCCE before and after 1-month combined treatment with WKC (0.9 g per time orally, 3 times per day). The gastrointestinal symptom score, gastric Lanza score, the duodenal, jejunal and ileal mucosal injury scores were used to evaluate the gastrointestinal injury before and after treatment. Adverse events including nausea, vomiting, abdominal pain, abdominal distension, abdominal discomfort, dizziness, or headache during MCCE and combined treatment were observed and recorded. Results: Twenty-two patients (male/female, 13/ 9) taking enteric-coated aspirin aged 59.5 +/- 11.3 years with a duration of aspirin use of 28.0 (1.0, 48.0) months were recruited. Compared with pre-treatment, the gastrointestinal symptom rating scale scores, gastric Lanza scores, and duodenal mucosal injury scores were significantly reduced after 1-month WKC treatment (P<0.05), and jejunal and ileal mucosal injury scores showed no obvious change. No adverse events occurred during the trial. Conclusions: WKC can alleviate gastrointestinal symptoms, as well as gastric and duodenal mucosal injuries, in patients taking enteric-coated aspirin; it does not aggravate jejunal or ileal mucosal injury, which may be an effective alternative for these patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available