Computer-Aided Living Polymerization Conducted under Continuous-Flow Conditions†

Comprehensive Summary Continuous-flow techniques have promoted the development of synthetic chemistry due to advantages such as outstanding mass/heat transfer, on-demand scalability, improved safety, precise regulation on reaction parameters, etc. Recently, the combination of flow polymerization with computer science has gained considerable interests, leading to a variety of cutting-edge synthetic techniques. This review summarizes emerging achievements realized via the integration of computer science and living flow polymerizations, including 1) high-throughput living polymerizations in flow, 2) programmable regulations of dispersity profile, sequence and topology for polymers, 3) modular design with online monitoring, as well as 4) self-optimized living polymerizations in flow. We expect that this summary will furnish informative knowledge to scientists in related directions and inspire new ideas to further empower on-demand polymer engineering with modern techniques.

Automated summary

Continuous-flow techniques combined with computer science have led to new breakthroughs in synthetic chemistry, including high-throughput living polymerizations and programmable regulations for polymers, advancing the field of polymer engineering with modern techniques.