Journal
CHINESE JOURNAL OF CHEMICAL ENGINEERING
Volume 39, Issue -, Pages 297-305Publisher
CHEMICAL INDUSTRY PRESS CO LTD
DOI: 10.1016/j.cjche.2021.06.015
Keywords
Poly (butylene succinate); Gelatin; Co-electrospinning; Degradation; Vascular graft
Categories
Funding
- National Natural Science Foundation of China [31870966, 81800931, 81901062]
- National Key Research Development Program of China [2020YFA0803701, 2017YFC1103504]
- Tianjin Science Foundation [20YFZCSY01020]
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This study prepared a series of PBSU/gelatin composites by electrospinning and evaluated their biomechanical properties, biocompatibility, and biodegradability. The results showed that the addition of gelatin improved the properties of PBSU, enhancing cell adhesion and promoting the growth of vascular smooth muscle cells.
In this study, a series of poly (butylene succinate) (PBSU)/gelatin composites were prepared by electrospinning. The morphology, physicochemical analysis, biomechanical properties, biocompatibility, and biodegradability of the materials were evaluated. The results showed that the ultimate tensile stress of the vascular PBSU/gelatin grafts at (95/5), (90/10), (85/15), and (80/20) was (4.17 +/- 0.54) MPa, (3.81 +/- 0.44) MPa, 2.94 +/- 0.69 MPa and 2.11 +/- 0.72 MPa respectively, and the burst pressure was (282. 7 +/- 22.3) kPa, (295.3 +/- 3.9) kPa, (306.8 +/- 13.9) kPa and (307.6 +/- 9.0) kPa respectively, which met the requirements of tissue-engineered blood vessels. Furthermore, the addition of gelatin improved the hydrophilicity and degradation properties of PBSU, thus enhancing cell adhesion and promoting the inward growth of vascular smooth muscle cells. In summary, the research in this paper provides a useful reference for the preparation and optimization of vascular scaffolds. (C) 2021 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.
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