Dearomative spirocyclization via visible-light-induced reductive hydroarylation of non-activated arenes

A visible-light-induced spirocyclizative hydroarylation via reductive dearomatization of a series of non-activated arenes including 2-phenyl indoles and naphthalene derivatives under mild conditions is described. An intriguing chemoselective dearomative hydroarylation of 2-phenyl indoles is presented. This dearomative hydroarylation protocol rapidly delivers valuable spirocycles with carbon-carbon double bonds from readily accessible aromatic precursors in a single step. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Automated summary

A visible-light-induced spirocyclizative hydroarylation via reductive dearomatization of non-activated arenes, including 2-phenyl indoles and naphthalene derivatives, is described. This protocol allows for the rapid synthesis of valuable spirocycles with carbon-carbon double bonds from readily accessible aromatic precursors in a single step.