Journal
CHEMPHYSCHEM
Volume 22, Issue 20, Pages 2128-2137Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.202100162
Keywords
NMR spectroscopy; spin-lock induced crossing; low-field NMR; J-coupling; dressed state
Funding
- NSF STTR [2014924]
- Dir for Tech, Innovation, & Partnerships
- Translational Impacts [2014924] Funding Source: National Science Foundation
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In this study, a new pulse sequence called spin-lock induced crossing (SLIC) was developed to acquire proton NMR spectra in the strong-coupling regime without the need for heteronuclei. The SLIC technique is able to produce unique J-coupling spectra for most organic molecules, showing good agreement between simulated and measured spectra for small molecules at different frequencies.
Nuclear magnetic resonance (NMR) spectroscopy usually requires high magnetic fields to create spectral resolution among different proton species. Although proton signals can also be detected at low fields the spectrum exhibits a single line if J-coupling is stronger than chemical shift dispersion. In this work, we demonstrate that the spectra can nevertheless be acquired in this strong-coupling regime using a novel pulse sequence called spin-lock induced crossing (SLIC). This techniques probes energy level crossings induced by a weak spin-locking pulse and produces a unique J-coupling spectrum for most organic molecules. Unlike other forms of low-field J-coupling spectroscopy, our technique does not require the presence of heteronuclei and can be used for most compounds in their native state. We performed SLIC spectroscopy on a number of small molecules at 276 kHz and 20.8 MHZ and show that the simulated SLIC spectra agree well with measurements.
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