Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents

Several naturally occurring cyclopentenones, such as palmenones and nigrosporiones, exhibit antimicrobial activity. Herein we describe the antimicrobial activity of cyclopentenones and derivatives that can be easily accessed from biomass derivatives furfural and 5-hydroxymethylfurfural. Upon screening a range of functionalized trans-diamino-cyclopentenones (DCPs) and delta-lactone-fused cyclopentenones (LCPs), an oxime ether derivative of DCP was identified that exhibited remarkable antimicrobial activity against Gram-positive bacteria, including resistant strains such as methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (VRE) strains.

Automated summary

Naturally occurring cyclopentenones, such as palmenones and nigrosporiones, show antimicrobial activity, and derivatives accessible from biomass derivatives furfural and 5-hydroxymethylfurfural were found to exhibit significant antimicrobial activity against Gram-positive bacteria, including resistant strains like MRSA and VRE.