4.6 Article

Enantioselectivity in Ruthenium-Catalyzed Propargylic Substitution Reactions of Propargylic Alcohols with Acetone: A DFT Study

Journal

CHEMISTRY-AN ASIAN JOURNAL
Volume 16, Issue 22, Pages 3760-3766

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202100984

Keywords

propargylic substitution reactions; thiolate-bridged diruthenium complexes; enantioselectivity; DFT calculations; intramolecular dispersion interactions

Funding

  1. JSPS [20H05671, 20K05532]
  2. Grants-in-Aid for Scientific Research [20H05671, 20K05532] Funding Source: KAKEN

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The enantioselectivity in propargylic substitution reactions catalyzed by optically active thiolate-bridged diruthenium complexes was investigated using DFT calculations. Transition-state structures leading to the major (R) product were found to be more abundant than those leading to the minor (S) product, suggesting a higher probability of forming the major product. The introduction of a phenyl group in the thiolate ligand was proposed to enhance selectivity, leading to a novel transition state model for the asymmetric catalytic reaction system.
The enantioselectivity in the propargylic substitution reactions of propargylic alcohols with acetone catalyzed by optically active thiolate-bridged diruthenium complexes was examined via omega B97X-D level DFT calculations. Some structures with intramolecular dispersion interactions between ligands were found for the ruthenium-allenylidene complex, which is the key intermediate in the catalytic reaction, and it was determined that the structure corresponding to the X-ray crystal structure, which had provided the transition state model for the enantioselectivity in previous studies, was not the most stable among the obtained structures. Then, a variety of transition-state structures for the nucleophilic attack of prop-1-ene-2-ol, which is the enol isomer of acetone, on the gamma-carbon of the ruthenium-allenylidene complex were explored. Among the transition-state structures with lower energies, the number of structures leading to the major (R) product was found to be larger than that of structures leading to the minor (S) product, providing enantioselectivity in terms of probability distributions. The introduction of a phenyl group in the thiolate ligand was suggested to increase the selectivity. Thus, we propose the novel transition state model for the asymmetric catalytic reaction system.

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