Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 16, Issue 18, Pages 2618-2621Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202100681
Keywords
visible light; photoredox catalysis; radical cascade cyclization; sulfonylation; sulfonylated benzo[4; 5]imidaz-o[2; 1-a]isoquinolin-6(5H)-ones
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Funding
- National Natural Science Foundation of China [82003567]
- Shanghai Sailing Program [20YF1414100]
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The visible-light-driven sulfonylation/cyclization of N-methacryloyl-2-phenylbenzoimidazoles has been successfully developed, providing a range of sulfonylated benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones with potential antitumor activity. This method offers mild reaction conditions and excellent functional group tolerance, serving as a new strategy for the development of potential antitumor lead compounds.
Visible-light-driven sulfonylation/cyclization of N-methacryloyl-2-phenylbenzoimidazoles has been successfully developed. Using commercially available sulfonyl chloride as sulfonylation reagent, a wide range of sulfonylated benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones with potential antitumor activity were provided in acceptable to excellent yields. This method has the advantages of mild reaction conditions and outstanding functional group tolerance, and provides a new strategy for the development of potential antitumor lead compounds.
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