Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 27, Issue 62, Pages 15327-15360Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202101768
Keywords
aldol; C-C bond formation; condensation; hydrogenation; reductive alkylation
Categories
Funding
- RSF [21-13-00157]
- Ministry of Science and Higher Education of the Russian Federation
- Russian Science Foundation [21-13-00157] Funding Source: Russian Science Foundation
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Efficient formation of saturated carbon-carbon bonds is crucial in organic synthesis, and reductive aldol-type reactions have gained increasing interest for their versatile applications. This review highlights the advantages and disadvantages of these reactions in total synthesis of pharmaceutical substances to encourage further research in the field.
The efficient chemo-, regio- and stereoselective formation of saturated carbon-carbon fragment is the critical challenge of organic synthesis; therefore, developing new methods for formation of these bonds is paramount. The rising interest for reductive aldol-type reactions is conditioned by its versatile applications, allowing the efficient formation of carbon-carbon bonds. The review aims to highlight the advantages and disadvantage of reductive aldol-type reactions to total synthesis of pharmaceutical substances in order to summarize knowledge and encourage further investigation of the field.
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