Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 27, Issue 45, Pages 11730-11737Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202101534
Keywords
carbon-based Lewis acids; homogeneous catalysis; hydrogen transfer; metal-free hydrodefluorination; silanes
Categories
Funding
- University of Toronto
- Natural Science and Engineering Research Council (NSERC)
- Guggenheim foundation
- Deutsche Forschungsgemeinschaft (DFG)
- DFG [EL 1045]
- NSERC-CGS-D scholarship
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The development of novel Lewis acids derived from bipyridinium and phenanthrolinium dications has shown high carbon-based Lewis acidity, making them effective catalysts for hydrodefluorination reactions. These Lewis acids are capable of generating catalytically active silylium cations and have been successfully used for the initiation of deuterodefluorination reactions. Experimental and computational data support the role of these dications as initiators in the generation of silylium cations.
The development of novel Lewis acids derived from bipyridinium and phenanthrolinium dications is reported. Calculations of Hydride Ion Affinity (HIA) values indicate high carbon-based Lewis acidity at the ortho and para positions. This arises in part from extensive LUMO delocalization across the aromatic backbones. Species [C10H6R2N2CH2CH2](2+) (R=H [1 a](2+), Me [1 f](2+), tBu [1 g](2+)), and [C12H4R4N2CH2CH2](2+) (R=H [2 a](2+), Me [2 b](2+)) were prepared and evaluated for use in the initiation of hydrodefluorination (HDF) catalysis. Compound [2 a](2+) proved highly effective towards generating catalytically active silylium cations via Lewis acid-mediated hydride abstraction from silane. This enabled the HDF of a range of aryl- and alkyl- substituted sp(3)(C-F) bonds under mild conditions. The protocol was also adapted to effect the deuterodefluorination of cis-2,4,6-(CF3)(3)C6H9. The dications are shown to act as hydride acceptors with the isolation of neutral species C16H14N2 (3 a) and C16H10Me4N2 (3 b) and monocationic species [C14H13N2](+) ([4 a](+)) and [C18H21N2]+ ([4 b](+)). Experimental and computational data provide further support that the dications are initiators in the generation of silylium cations.
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