Journal
CHEMISTRY & BIODIVERSITY
Volume 18, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202100512
Keywords
Aspergillus insuetus; cold seep-derived fungus; marine natural products; antibacterial activity
Funding
- National Key R&D Program of China [2018YFC0310800]
- National Natural Science Foundation of China [42076090, U2006203]
- Shandong Provincial Natural Science Foundation [ZR2019ZD18]
- Basic Applied Research program of Qingdao [19-6-2-40-cg]
- Senior User Project of RV KEXUE [KEXUE2020GZ02]
- Center for Ocean Mega-Science, Chinese Academy of Sciences
- Taishan Scholar Project from Shandong Province [ts201511060]
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Two new phenol derivatives, insphenol A and acetylpeniciphenol, along with seven known analogs, were isolated from the deep-sea cold seep-derived fungus Aspergillus insuetus SD-512. Insphenol A represents the first example of isopentenyl phenol derivative with a unique 1-glycosylation from the species Aspergillus insuetus. Acetylpeniciphenol showed inhibitory effects against three pathogens.
Two new phenol derivatives, namely insphenol A (1) and acetylpeniciphenol (2), along with seven known analogs (3-9), were isolated from the deep-sea cold seep-derived fungus, Aspergillus insuetus SD-512. The structures of 1 and 2 were established by extensive interpretation of NMR and mass spectroscopic data. The absolute configuration of 1 was determined by the combination of coupling constant analysis and acid hydrolysis. Among the isolated compounds, insphenol A (1) represents the first example of isopentenyl phenol derivative with a unique 1-glycosylation from the species Aspergillus insuetus. The isolated new compounds were evaluated for antibacterial activities against six human or aquatic pathogens, while compound 2 exhibited inhibitory effect against Edwardsiella tarda, Vibrio alginolyticus, and V. vulnificus, with MIC values of 4, 8, and 8 mu g/mL, respectively.
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